BACKGROUND: Scarce information exists regarding the preventive effect of periodontal treatment in the recurrence of cardiovascular events. Prevention may be achieved by targeting risk factors for recurrent coronary artery disease (CAD) in patients with previous history of cardiovascular events. The aim of this trial is to compare the effect of two periodontal treatment approaches on levels of C-reactive protein, lipids, flow-mediated dilation and serum concentrations of proinflammatory and endothelial markers in stable CAD patients with periodontitis over a period of 12 months. METHODS/DESIGN: This is a randomized, parallel design, examiner blinded, controlled clinical trial. Individuals from both genders, 35 years of age and older, with concomitant diagnosis of CAD and periodontitis will be included. CAD will be defined as the occurrence of at least one of the following events 6 months prior to entering the trial: documented history of myocardial infarction; surgical or percutaneous myocardial revascularization and lesion >50% in at least one coronary artery assessed by angiography; presence of angina and positive noninvasive testing of ischemia. Diagnosis of periodontitis will be defined using the CDC-AAP case definition (>/=2 interproximal sites with clinical attachment loss >/=6 mm and >/=1 interproximal site with probing depth >/=5 mm). Individuals will have to present at least ten teeth present to be included. One hundred individuals will be allocated to test (intensive periodontal treatment comprised by scaling and root planing) or control (community periodontal treatment consisting of one session of supragingival plaque removal only) treatment groups. Full-mouth six sites per tooth periodontal examinations and subgingival biofilm samples will be conducted at baseline, 3, 6 and 12 months after treatment. The primary outcome of this study will be C-reactive protein changes over time. Secondary outcomes include levels of total cholesterol, LDL-C, HDL-C, triglycerides, IL-1beta, IL-6, TNFalpha, fibrinogen, ICAM-1, VCAM-1 and E-selectin. These outcomes will be assessed at all time points over 12 months. Flow-mediated dilation will be assessed at baseline, 1, 3 and 6 months after periodontal therapy. DISCUSSION: This trial will provide new evidence regarding the effect of periodontal treatment on risk markers for recurrence of cardiovascular events in stable coronary artery disease patients. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier, NCT01609725.

O externalismo semântico (a tese segundo a qual valores semânticos são, ao menos parcialmente, constituídos pelas relações não-representacionais dos usuários da linguagem com seu ambiente natural e social) é apresentado aqui em perspectiva histórica. Na reconstrução proposta, a genealogia da tese exposta e defendida por Hilary Putnam no clássico 'The meaning of "meaning"' (1975) remonta à filosofia da linguagem de Bertrand Russell nos anos 1903-1914 (em particular, à concepção russelliana da semântica dos termos singulares). A tese foi então gradualmente articulada na crítica à compreensão dita 'descritivista' da referência que emergiu da obra pioneira de Ruth Barcan Marcus em lógica modal quantificada e foi sistematizada por filósofos como Keith Donnellan, David Kaplan e, sobretudo, Saul A. Kripke. A este último, em particular, deve-se a introdução da noção de designação rígida que, estendida aos designadores de espécies naturais, abriria o caminho, finalmente, para a formulação madura do externalismo semântico no 'locus classicus' de Putnam.

The South America southern coast exhibits many outcrops with abundant shell beds, from the Pleistocene through the Recent. How much biological information is preserved within these shell beds? Or, what is the actual probability a living community has to leave a fossil record corresponding to these shell deposits? Although ecological and biogeographical aspects might had been pointed, considering these temporal scales, up to the moment there is no taphonomically-oriented studies available. Quantitative comparisons between living (LAs), death (DAs) and fossil assemblages (FAs) are important not only in strictly taphonomic studies, but have grown a leading tool for conservation paleobiology analysis. Comparing LAs, DAs and FAs from estuaries and lagoons in the Rio Grande do Sul Coastal Plain makes possible to quantitatively understand the nature and quantity of biological information preserved in fossil associations in Holocene lagoon facies. As already noted by several authors, spatial scale parts the analysis, but we detected that the FAs reflects live ones, rather than dead ones, as previously not realized. The results herein obtained illustrates that species present in DA are not as good preserved in recent (Holocene) fossil record as originally thought. Strictly lagoon species are most prone to leave fossil record. The authors consider that the fidelity pattern here observed for estuarine mollusks to be driven by (i) high temporal and spatial variability in the LAs, (ii) spatial mixing in the DA and (iii) differential preservation of shells, due to long residence times in the taphonomically active zone. © 2013 by the Sociedade Brasileira de Paleontologia.

The Prediction Error Method (PEM) is related to an optimization problem built on input/output data collected from the system to be identified. It is often hard to find the global solution of this optimization problem because the corresponding objective function presents local minima and/or the search space is constrained to a nonconvex set. The shape of the cost function, and hence the difficulty in solving the optimization problem, depends directly on the experimental conditions, more specifically on the spectrum of the input/output data collected from the system. Therefore, it seems plausible to improve the convergence to the global minimum by properly choosing the spectrum of the input; in this paper, we address this problem. We present a condition for convergence to the global minimum of the cost function and propose its inclusion in the input design. We present the application of the proposed approach to case studies where the algorithms tend to get trapped in nonglobal minima.