{Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women}

Citation:
Gonçalves, TL, Erthal F, Corte CLD, Müller LG, Piovezan CM, Nogueira CW, Rocha JBT.  2005.  {Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women}. Clinical Biochemistry. 38, Number 12

Abstract:

Objectives: To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states. Design and methods: Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood $δ$-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls. Results: Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion-LSIL and high squamous intraepithelial lesion-HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P {\textless} 0.01). Plasma vitamin C was lower in the carcinoma group (P {\textless} 0.01). The reactivation index of $δ$-aminolevulinate dehydratase ($δ$-ALA-D) was higher in the patient group, when compared to control (P {\textless} 0.01). Conclusion: LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis. © 2005 The Canadian Society of Clinical Chemists. All rights reserved.

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