Montenegro, MM, Ribeiro IWJ, Kampits C, Saffi MAL, Furtado MV, Polanczyk CA, Haas AN, Rosing CK.
2019.
Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months, Mar. J Clin Periodontol. 46:321-331., Number 3
AbstractMontenegro, Marlon MRibeiro, Ingrid W JKampits, CassioSaffi, Marco A LFurtado, Mariana VPolanczyk, Carisi AHaas, Alex NRosing, Cassiano KengRandomized Controlled TrialResearch Support, Non-U.S. Gov'tJ Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6.
AIM: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers. MATERIALS AND METHODS: This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C-reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL-1beta, IL-6, IL-8, IL-10, IFN-gamma and TNF-alpha) were measured at baseline and after 3 months. RESULTS: Eighty-two patients (74.4% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP <3 mg/L, a significant increase in CRP was observed in CG (1.44 +/- 0.82 mg/L to 4.35 +/- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +/- 0.96 mg/L to 1.33 +/- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP >/=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +/- 12.8 mg/L to 5.7 +/- 4.1 mg/L, p = 0.04). Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months. CONCLUSIONS: PT leads to lower levels of CRP, IL-6 and IL-8 in cardiovascular patients with high CRP levels.
Nuernberg, MAA, Ivanaga CA, Haas AN, Aranega AM, Casarin RCV, Caminaga RMS, Garcia VG, Theodoro LH.
2019.
Periodontal status of individuals with Down syndrome: sociodemographic, behavioural and family perception influence, Oct. J Intellect Disabil Res. 63:1181-1192., Number 10
AbstractNuernberg, M A AIvanaga, C AHaas, A NAranega, A MCasarin, R C VCaminaga, R M SGarcia, V GTheodoro, L HengObservational StudyEnglandJ Intellect Disabil Res. 2019 Oct;63(10):1181-1192. doi: 10.1111/jir.12629. Epub 2019 May 7.
BACKGROUND: The aim of the present study was to assess the periodontal condition of individuals with Down syndrome and the association with sociodemographic and behavioural characteristics and family perception of oral health. METHODS: This cross-sectional observational study was performed at a referral centre for dental assistance to disabled persons in Aracatuba, Brazil. Parents of the individuals were interviewed, and the visible plaque index, bleeding on probing, probing pocket depth and clinical attachment level were recorded by one periodontist in six sites per tooth of all teeth. The individual was the unit of analysis. The significance level was set at 5%. RESULTS: Sixty-four subjects (23.8 +/- 8.3 years old) were included. Eighteen (28.1%) were diagnosed with gingivitis and 46 (71.9%) with periodontitis. In the multiple logistic regression final model, age and self-reported oral hygiene practices were associated with the occurrence of periodontitis. The chance of having periodontitis was 4.7 times higher among individuals older than 20 years and approximately 4 times higher in patients whose oral hygiene was performed by themselves and their parents, compared with those who performed oral hygiene alone. Sex, follow-up time in the centre, education, degree of participants' dependence, flossing and family history of periodontal disease were not associated with the occurrence of periodontitis. Higher levels of plaque and bleeding were observed for participants with parents reporting bad gingival health (76.2% and 46.9%) and deficient oral hygiene (79.5% and 47.3%). The perception of parents regarding gingival bleeding was correlated with higher bleeding detected clinically (P = 0.01; 50.1%). CONCLUSIONS: The prevalence of periodontitis in individuals with Down syndrome is high and increases with age, even in the face of the parents' perception about their children's oral condition.
Mendonca, DD, Furtado MV, Sarmento RA, Nicoletto BB, Souza GC, Wagner TP, Christofoli BR, Polanczyk CA, Haas AN.
2019.
Periodontitis and tooth loss have negative impact on dietary intake: A cross-sectional study with stable coronary artery disease patients, Oct. J Periodontol. 90:1096-1105., Number 10
AbstractMendonca, Dayana DFurtado, Mariana VSarmento, Roberta ANicoletto, Bruna BSouza, Gabriela CWagner, Tassiane PChristofoli, Barbara RPolanczyk, Carisi AHaas, Alex NengResearch Support, Non-U.S. Gov'tJ Periodontol. 2019 Oct;90(10):1096-1105. doi: 10.1002/JPER.19-0036. Epub 2019 May 27.
BACKGROUND: Despite the association between cardiovascular diseases and periodontitis, there are scarce data on the impact of oral health in the dietary intake of patients with coronary artery disease (CAD). The aim of this study was to assess the association between dietary intake with periodontitis and present teeth in individuals with stable CAD. METHODS: This cross-sectional study included 115 patients with stable CAD (76 males, aged 61.0 +/- 8.3 years) who were under cardiovascular care in an outpatient clinic for at least 3 months. Dietary intake was recorded applying a food frequency questionnaire previously validated. Periodontal examinations were performed by two calibrated examiners in six sites per tooth from all present teeth. Blood samples were collected to determine serum levels of lipids. Multivariable logistic and linear regression models were fitted to evaluate the association between dietary outcomes and oral health variables. RESULTS: Individuals with periodontitis had significantly higher percentage of total energy intake from fried foods, sweets, and beans, and also had lower consumption of fruits than those without periodontitis. Presence of periodontitis was associated with lower percentage of individuals who reached the nutritional recommendation of monounsaturated fatty acids and higher blood concentration of triglycerides. Having a greater number of present teeth (>/=20 teeth) was associated with higher intake of fibers and total calories. CONCLUSION: In patients with stable CAD, the presence of periodontitis and tooth loss were associated with a poor dietary intake of nutrients and healthy foods, which are important for cardiovascular prevention.