Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross-sectional study

Citation:
Schutz, JDS, de Azambuja CB, Cunha GR, Cavagni J, Rosing CK, Haas AN, Thome FS, Fiorini T.  2020.  Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross-sectional study, Mar. Oral Dis. 26:447-456., Number 2

Abstract:

OBJECTIVE: The aim of this cross-sectional study was to evaluate the association between periodontitis and different severities of chronic kidney disease (CKD) in predialytic patients. MATERIALS AND METHODS: Demographic, socioeconomic, and medical data of 139 patients from the nephrology service of one university hospital in Porto Alegre, Brazil, were obtained through interview and clinical records. Full-mouth six-sites per tooth periodontal examinations were performed. Associations between periodontitis, stages of CKD, and estimated glomerular filtration rate (eGFR) were estimated by multivariable models adjusted for sex, smoking, vitamin D supplementation, physical activity, and renal treatment duration. CKD was classified based on eGFR (<60 ml/min/1.73 m(2) ) estimated by the Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS: Patients with severe periodontitis, compared to those without severe periodontitis, had 2.8 (95% CI: 1.25-6.62) and 3.4 (95% CI: 1.27-9.09) times higher risk of being in stages 4 and 5 of CKD, respectively. Having >/= 2 teeth with clinical attachment loss (CAL) >/=6 mm increased 3.9 times the risk of being in stage 5 of CKD. Patients with severe periodontitis and >/=2 teeth with CAL >/= 6 mm had 4.4 ml/min/1.73(2) and 5.2 ml/min/1.73(2) lower eGFR (p-values < .05), respectively. CONCLUSION: Severe periodontitis was associated with poor renal conditions in predialytic CKD patients, strengthening the importance of periodontal evaluation in such patient population.

Notes:

Schutz, Jasper da Silvade Azambuja, Carolina BarreraCunha, Giuliano ReolonCavagni, JulianoRosing, Cassiano KuchenbeckerHaas, Alex NogueiraThome, Fernando SaldanhaFiorini, Tiagoeng150319/Hospital de Clinicas de Porto Alegre160428/Hospital de Clinicas de Porto AlegreDenmarkOral Dis. 2020 Mar;26(2):447-456. doi: 10.1111/odi.13236. Epub 2019 Dec 5.

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