Influence of supragingival biofilm control and smoking habit on Interleukin-1beta concentration

Citation:
Gomes, SC, Abascal CC, Haas AN, Angst PD, Oppermann RV, Marcantonio RA.  2015.  Influence of supragingival biofilm control and smoking habit on Interleukin-1beta concentration. Braz Oral Res. 29:S1806-83242015000100302., Number 1

Abstract:

This investigation compared gingival crevicular fluid (GCF) interleukin-1beta (IL-1beta) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 +/- 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6-10 mm) were obtained at the baseline, 30, and 180 days. IL-1beta was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1beta changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1beta concentrations decreased from 3.2 pg/microL to 1.9 pg/microL. Higher baseline IL-1beta concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1beta concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1beta concentrations. A strict Supra regimen reduced IL-1beta concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.

Notes:

Gomes, Sabrina CarvalhoAbascal, Carolina CoradiniHaas, Alex NogueiraAngst, Patricia Daniela MelchiorsOppermann, Rui VicenteMarcantonio, Rosemary Adriana ChiericiengComparative StudyBrazilBraz Oral Res. 2015;29(1):S1806-83242015000100302. doi: 10.1590/1807-3107BOR-2015.vol29.0115. Epub 2015 Oct 9.

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