@article {Goncalves2005,
	title = {{Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women}},
	journal = {Clinical Biochemistry},
	volume = {38},
	number = {12},
	year = {2005},
	note = {n/a},
	abstract = {<p>Objectives: To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states. Design and methods: Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood $δ$-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls. Results: Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion-LSIL and high squamous intraepithelial lesion-HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P {\textless} 0.01). Plasma vitamin C was lower in the carcinoma group (P {\textless} 0.01). The reactivation index of $δ$-aminolevulinate dehydratase ($δ$-ALA-D) was higher in the patient group, when compared to control (P {\textless} 0.01). Conclusion: LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis. {\textcopyright} 2005 The Canadian Society of Clinical Chemists. All rights reserved.</p>
},
	keywords = {ALA-D, Cervical cancer, Oxidative stress, Pre-malignant states, TBARS, Vitamin C},
	issn = {00099120},
	doi = {10.1016/j.clinbiochem.2005.09.008},
	author = {Gon{\c c}alves, T.L. and Erthal, F. and Corte, C.L.D. and M{\"u}ller, L.G. and Piovezan, C.M. and Nogueira, C.W. and Rocha, J. B. T.}
}
