@article {706,
	title = {Periodontal status affects C-reactive protein and lipids in patients with stable heart disease from a tertiary care cardiovascular clinic},
	journal = {J Periodontol},
	volume = {85},
	number = {4},
	year = {2014},
	note = {<p>Flores, Manuela FMontenegro, Marlon MFurtado, Mariana VPolanczyk, Carisi ARosing, Cassiano KHaas, Alex Neng2013/06/29 06:00J Periodontol. 2014 Apr;85(4):545-53. doi: 10.1902/jop.2013.130255. Epub 2013 Jun 27.</p>
},
	month = {Apr},
	pages = {545-53},
	abstract = {<p>BACKGROUND: There are scarce data on the impact of the periodontal condition in the control of biomarkers in patients with cardiovascular disease (CVD). The aim of this study is to assess whether periodontal inflammation and tissue breakdown are associated with C-reactive protein (CRP) and lipids in patients with stable heart disease. METHODS: This cross-sectional study included 93 patients with stable coronary artery disease (57 males; mean age: 63.5 +/- 9.8 years) who were in outpatient care for at least 6 months. After applying a structured questionnaire, periodontal examinations were performed by two calibrated periodontists in six sites per tooth at all teeth. Blood samples were collected from patients on the day of periodontal examination to determine levels of CRP, lipids, and glycated hemoglobin. Multiple linear regression models were fitted to evaluate the association among different periodontal and blood parameters controlling for sex, body mass index, glycated hemoglobin, use of oral hypoglycemic drugs, and smoking. RESULTS: Overall, the sample presented high levels of periodontal inflammation and tissue breakdown. Unadjusted mean concentrations of triglycerides (TGs), very-low-density lipoprotein cholesterol, and glucose were significantly higher in individuals with severe periodontitis. When multiple linear regression models were applied, number of teeth with clinical attachment loss \&gt;/=6 mm and presence of severe periodontitis were significantly associated with higher CRP concentrations. Bleeding on probing was significantly associated with TGs, total cholesterol, and non-high-density lipoprotein cholesterol. CONCLUSION: In this sample of patients with stable CVD, current periodontal inflammation and tissue breakdown are associated with cardiovascular inflammatory markers, such as CRP and lipid profile.</p>
},
	isbn = {1943-3670 (Electronic)0022-3492 (Linking)},
	url = {http://www.ncbi.nlm.nih.gov/pubmed/23805809},
	author = {Flores, M. F. and Montenegro, M. M. and Furtado, M. V. and Polanczyk, C. A. and Rosing, C. K. and Haas, A. N.}
}
