@article {6605,
	title = {Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months},
	journal = {J Clin Periodontol},
	volume = {46},
	number = {3},
	year = {2019},
	note = {<p>Montenegro, Marlon MRibeiro, Ingrid W JKampits, CassioSaffi, Marco A LFurtado, Mariana VPolanczyk, Carisi AHaas, Alex NRosing, Cassiano KengRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}tJ Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6.</p>
},
	month = {Mar},
	pages = {321-331},
	edition = {2019/02/15},
	abstract = {<p>AIM: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers. MATERIALS AND METHODS: This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C-reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL-1beta, IL-6, IL-8, IL-10, IFN-gamma and TNF-alpha) were measured at baseline and after 3 months. RESULTS: Eighty-two patients (74.4\% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP \&lt;3 mg/L, a significant increase in CRP was observed in CG (1.44 +/- 0.82 mg/L to 4.35 +/- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +/- 0.96 mg/L to 1.33 +/- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP \&gt;/=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +/- 12.8 mg/L to 5.7 +/- 4.1 mg/L, p = 0.04). Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months. CONCLUSIONS: PT leads to lower levels of CRP, IL-6 and IL-8 in cardiovascular patients with high CRP levels.</p>
},
	keywords = {*C-reactive protein, *cardiovascular disease, *Cardiovascular Diseases, *Coronary Artery Disease, *cytokines, *periodontal disease, Biomarkers, C-Reactive Protein, Female, Humans, Male, Middle Aged, Risk Factors, Single-Blind Method},
	isbn = {1600-051X (Electronic)0303-6979 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/30761568},
	author = {Montenegro, M. M. and Ribeiro, I. W. J. and Kampits, C. and Saffi, M. A. L. and Furtado, M. V. and Polanczyk, C. A. and Haas, A. N. and Rosing, C. K.}
}
