@article {6600,
	title = {Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial},
	journal = {Oral Dis},
	volume = {24},
	number = {7},
	year = {2018},
	note = {<p>Saffi, Marco Aurelio LRabelo-Silva, Eneida RPolanczyk, Carisi AFurtado, Mariana VMontenegro, Marlon MRibeiro, Ingrid W JKampits, CassioRosing, Cassiano KHaas, Alex NengCNPq 476387/2010-8/Brazilian Ministry of Science and TechnologyFAPERGS 1008214/Research Support Agency from Rio Grande do Sul StateRandomized Controlled TrialDenmarkOral Dis. 2018 Oct;24(7):1349-1357. doi: 10.1111/odi.12909. Epub 2018 Jul 10.</p>
},
	month = {Oct},
	pages = {1349-1357},
	edition = {2018/06/07},
	abstract = {<p>OBJECTIVE: To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease. MATERIALS AND METHODS: A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received nonsurgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling, and root planing per quadrant, whereas the control group received equal treatment after the study period. Endothelial function was assessed by measurement of brachial artery flow-mediated dilation, concentrations of sVCAM-1, sICAM-1, and P-selectin in serum before and 3 months after periodontal therapy. RESULTS: The test group exhibited statistically better periodontal parameters-plaque, probing depth, periodontal attachment loss, and bleeding on probing. No significant improvements were observed in the control (1.37\%) and test (1.39\%) groups in flow-mediated dilation, with no significant between-group difference. sVCAM-1 concentration increased in the control group (997.6 +/- 384.4-1201.8 +/- 412.5; p = 0.03), whereas in the test group, no significant changes were observed (915.1 +/- 303.8-1050.3 +/- 492.3; p = 0.17), resulting in a significant difference between the two groups (p = 0.04). The same pattern was observed for concentrations of sICAM-1. CONCLUSION: Periodontal treatment did not provide better vasodilation in patients with coronary disease in a short-term follow-up period, although it maintained blood concentrations of markers of vascular inflammation.</p>
},
	keywords = {Aged, Atherosclerosis, Coronary Artery Disease/complications/*physiopathology, Endothelium, Vascular/*physiopathology, Female, flow-mediated dilation, Humans, Intercellular Adhesion Molecule-1/blood, Male, Middle Aged, Oral Hygiene, P-Selectin/blood, Patient Education as Topic, periodontitis, Periodontitis/complications/*therapy, Root Planing, Single-Blind Method, Vascular Cell Adhesion Molecule-1/blood, vascular endothelium, Vasodilation/physiology},
	isbn = {1601-0825 (Electronic)1354-523X (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/29873864},
	author = {Saffi, M. A. L. and Rabelo-Silva, E. R. and Polanczyk, C. A. and Furtado, M. V. and Montenegro, M. M. and Ribeiro, I. W. J. and Kampits, C. and Rosing, C. K. and Haas, A. N.}
}
