@article {6599,
	title = {Vitamin D levels and risk for periodontal disease: A systematic review},
	journal = {J Periodontal Res},
	volume = {53},
	number = {3},
	year = {2018},
	note = {<p>Pinto, J P N SGoergen, JMuniz, F W M GHaas, A NengSystematic ReviewJ Periodontal Res. 2018 Jun;53(3):298-305. doi: 10.1111/jre.12531. Epub 2018 Mar 1.</p>
},
	month = {Jun},
	pages = {298-305},
	edition = {2018/03/02},
	abstract = {<p>OBJECTIVE: To evaluate the existing evidence supporting or refuting the following questions: (i) Do patients with lower vitamin D levels have higher risk for periodontal disease? (ii) Are periodontal treatment outcomes improved by the adjuvant supplementation of vitamin D or by elevated serum vitamin D levels? MATERIAL AND METHODS: MEDLINE, SCOPUS, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched up to September 2017. Studies were included if they had measured serum vitamin D levels or vitamin D intake and any periodontal parameter. RESULTS: Overall, 27 studies were included (13 cross-sectional studies, 6 case-control studies, 5 cohort studies, 2 randomized clinical trials and 1 case series study). Sixty-five percent of the cross-sectional studies reported significant associations between low vitamin D levels and poor periodontal parameters. None of the observational longitudinal studies found that periodontal disease progression could be attributed to lower vitamin D levels. No interventional studies that evaluated the use of vitamin D supplementation as a solely adjuvant to periodontal treatment was found. No meta-analysis was performed due to high variability across studies. CONCLUSION: The data to support or refute the association between vitamin D levels and periodontal disease are inconclusive at the moment. More rigorously designed longitudinal studies with standardized definitions of periodontal disease and vitamin D are necessary.</p>
},
	keywords = {Databases, Factual, Dietary Supplements, epidemiology, Humans, periodontal disease, Periodontal Diseases/*blood/epidemiology/etiology, Randomized Controlled Trials as Topic, Risk Factors, systematic review, vitamin D, Vitamin D/administration \& dosage/*blood},
	isbn = {1600-0765 (Electronic)0022-3484 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/29492977},
	author = {Pinto, Jpns and Goergen, J. and Muniz, Fwmg and Haas, A. N.}
}
