@article {6594,
	title = {Periodontal disease, tooth loss and coronary heart disease assessed by coronary angiography: a cross-sectional observational study},
	journal = {J Periodontal Res},
	volume = {51},
	number = {2},
	year = {2016},
	note = {<p>Zanella, S MPereira, S SBarbisan, J NVieira, LSaba-Chujfi, EHaas, A NRosing, C KengJ Periodontal Res. 2016 Apr;51(2):221-7. doi: 10.1111/jre.12301. Epub 2015 Jul 30.</p>
},
	month = {Apr},
	pages = {221-7},
	edition = {2015/08/01},
	abstract = {<p>OBJECTIVE AND BACKGROUND: To evaluate the association between periodontal disease, tooth loss and coronary heart disease (CHD). There is still controversy about the relationship between periodontal disease and tooth loss with vessel obstruction assessed using coronary angiography. MATERIAL AND METHODS: This cross-sectional study included 195 patients that underwent coronary angiography and presented with at least six teeth. Patients were classified into three categories of coronary obstruction severity: absence; one or more vessels with /= 50\% obstruction. The extent of coronary obstruction was dichotomized into 0 and \&gt;/= 1 affected vessels. A periodontist blinded to patient CHD status conducted a full mouth examination to determine mean clinical attachment loss, mean periodontal probing depth and tooth loss. Multiple logistic regression models were applied adjusting for age, gender, hypertension, smoking, body mass index, low-density lipoprotein cholesterol and C-reactive protein. RESULTS: Most patients were males (62.1\%) older than 60 years (50.8\%), and 61\% of them had CHD. Mean periodontal probing depth, clinical attachment loss and tooth loss were 2.64 +/- 0.72 mm, 4.40 +/- 1.31 mm and 12.50 +/- 6.98 teeth respectively. In the multivariable models, tooth loss was significantly associated with a higher chance of having at least one obstructed vessel (odds ratio = 1.04; 95\% confidence interval 1.01-1.09) and with vessel obstruction \&gt;/= 50\% (odds ratio = 1.06; 95\% confidence interval 1.01-1.11). No significant associations were found between periodontal variables and vessel obstruction. CONCLUSION: Tooth loss was found to be a risk indicator for CHD.</p>
},
	keywords = {*periodontal diseases, Coronary Angiography, Coronary Disease, Cross-Sectional Studies, Humans, Male, Periodontal Attachment Loss, periodontal disease, Risk Factors, Smoking, Tooth Loss},
	isbn = {1600-0765 (Electronic)0022-3484 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/26223630},
	author = {Zanella, S. M. and Pereira, S. S. and Barbisan, J. N. and Vieira, L. and Saba-Chujfi, E. and Haas, A. N. and Rosing, C. K.}
}
