@article {6589,
	title = {Periodontal disease and inflammatory blood cytokines in patients with stable coronary artery disease},
	journal = {J Appl Oral Sci},
	volume = {24},
	number = {4},
	year = {2016},
	note = {<p>Kampits, CassioMontenegro, Marlon MRibeiro, Ingrid W JFurtado, Mariana VPolanczyk, Carisi ARosing, Cassiano KHaas, Alex NengBrazilJ Appl Oral Sci. 2016 Jul-Aug;24(4):352-8. doi: 10.1590/1678-775720160082.</p>
},
	month = {Jul-Aug},
	pages = {352-8},
	edition = {2016/08/25},
	abstract = {<p>MATERIAL AND METHODS: This cross-sectional study included 91 patients with stable CAD who had been under optimized cardiovascular care. Blood levels of IL-1beta, IL-6, IL-8, IL-10, IFN-gamma, and TNF-alpha were measured by Luminex technology. A full-mouth periodontal examination was conducted to record probing depth (PD) and clinical attachment (CA) loss. Multiple linear regression models, adjusting for gender, body mass index, oral hypoglycemic drugs, smoking, and occurre:nce of acute myocardial infarction were applied. RESULTS: CAD patients that experienced major events had higher concentrations of IFN-gamma (median: 5.05 pg/mL vs. 3.01 pg/mL; p=0.01), IL-10 (median: 2.33 pg/mL vs. 1.01 pg/mL; p=0.03), and TNF-alpha (median: 9.17 pg/mL vs. 7.47 pg/mL; p=0.02). Higher numbers of teeth with at least 6 mm of CA loss (R2=0.07) and PD (R2=0.06) were significantly associated with higher IFN-gamma log concentrations. Mean CA loss (R2=0.05) and PD (R2=0.06) were significantly related to IL-10 concentrations. Elevated concentrations of TNF-alpha were associated with higher mean CA loss (R2=0.07). CONCLUSION: Periodontal disease is associated with increased systemic inflammation in stable cardiovascular patients. These findings provide additional evidence supporting the idea that periodontal disease can be a prognostic factor in cardiovascular patients.</p>
},
	keywords = {Aged, Biomarkers/blood, Coronary Artery Disease/*blood/physiopathology, Cross-Sectional Studies, Female, Humans, Interferon-gamma/*blood, Interleukins/*blood, Linear Models, Male, Middle Aged, Periodontal Attachment Loss, Periodontal Diseases/*blood/physiopathology, Periodontal Index, Predictive Value of Tests, Reference Values, Risk Factors, Smoking/adverse effects, Surveys and Questionnaires, Tumor Necrosis Factor-alpha/*blood},
	isbn = {1678-7765 (Electronic)1678-7757 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/27556206},
	author = {Kampits, C. and Montenegro, M. M. and Ribeiro, I. W. and Furtado, M. V. and Polanczyk, C. A. and Rosing, C. K. and Haas, A. N.}
}
