@article {6588,
	title = {Essential oils-containing mouthwashes for gingivitis and plaque: Meta-analyses and meta-regression},
	journal = {J Dent},
	volume = {55},
	year = {2016},
	note = {<p>Haas, Alex NogueiraWagner, Tassiane PantaMuniz, Francisco Wilker Mustafa GomesFiorini, TiagoCavagni, JulianoCeleste, Roger KellerengMeta-AnalysisReviewEnglandJ Dent. 2016 Dec;55:7-15. doi: 10.1016/j.jdent.2016.09.001. Epub 2016 Sep 11.</p>
},
	month = {Dec},
	pages = {7-15},
	edition = {2016/09/16},
	abstract = {<p>OBJECTIVES: To evaluate the efficacy of EO as adjuncts to mechanical plaque control (MPC) on the reduction of plaque and gingivitis when compared to placebo or cetylpyridium chloride (CPC). DATA: Randomized controlled trials of at least 6 months of follow-up including systemically healthy individuals with gingivitis were included. SOURCES: MEDLINE, EMBASE, Lilacs and SCOPUS were searched up to April 2016. From 3045 citations, 16 studies were included. 14 studies assessed the Quigley-Hein Plaque Index (QHI) and 11 studies assessed the Modified Gingival Index (MGI) and were included in meta-analyses and meta-regression. STUDY SELECTION: The analysis of risk of bias suggested that the quality of the studies ranged from moderate to low. Mean QHI (WMD=-0.86, 95\%CI -1.05 to -0.66) and MGI (WMD=-0.52, 95\%CI -0.67 to -0.37) were lower for EO+MPC than placebo+MPC. Reductions in plaque and gingivitis were, respectively, 32\% and 24\% larger for EO+MPC than placebo+MPC. The decreases in QHI (WMD=-0.95, 95\%CI -1.26 to -0.63) and in MGI (WMD=-0.34, 95\%CI -0.53 to -0.15) observed in the EO+MPC group, compared to placebo+MPC in interproximal areas, were significantly different and in favor to EO+MPC. EO+MPC compared to CPC+MPC resulted in clinically lower levels of plaque and gingivitis. High heterogeneity (I(2)\&gt;95\%) was found and explained (MGI-R(2)=63.6\%; QHI-R(2)=80.1\%) by differences between studies in the percentage of males, supervision of the mouthwashes and provision of oral hygiene. CONCLUSIONS: EO seems to be superior to placebo+MPC and CPC+MPC for reduction of plaque and gingival inflammation in patients with gingivitis. Expected benefits may be clinically relevant and may also reach the interproximal area. CLINICAL SIGNIFICANCE: Mouthwashes containing essential oils should be considered the first choice for daily use as adjuvants to self-performed mechanical plaque control.</p>
},
	keywords = {*Cetylpyridinium, *Dental plaque, *Essential oils, *Gingivitis, *Meta-analysis, *Mouthwashes, Anti-Infective Agents, Local, Dental Plaque, Dental Plaque Index, Gingivitis, Humans, Male, Oils, Volatile, Periodontal Index},
	isbn = {1879-176X (Electronic)0300-5712 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/27628316},
	author = {Haas, A. N. and Wagner, T. P. and Muniz, Fwmg and Fiorini, T. and Cavagni, J. and Celeste, R. K.}
}
