@article {6581,
	title = {Influence of supragingival biofilm control and smoking habit on Interleukin-1beta concentration},
	journal = {Braz Oral Res},
	volume = {29},
	number = {1},
	year = {2015},
	note = {<p>Gomes, Sabrina CarvalhoAbascal, Carolina CoradiniHaas, Alex NogueiraAngst, Patricia Daniela MelchiorsOppermann, Rui VicenteMarcantonio, Rosemary Adriana ChiericiengComparative StudyBrazilBraz Oral Res. 2015;29(1):S1806-83242015000100302. doi: 10.1590/1807-3107BOR-2015.vol29.0115. Epub 2015 Oct 9.</p>
},
	pages = {S1806-83242015000100302},
	edition = {2016/02/20},
	abstract = {<p>This investigation compared gingival crevicular fluid (GCF) interleukin-1beta (IL-1beta) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 +/- 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6-10 mm) were obtained at the baseline, 30, and 180 days. IL-1beta was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1beta changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1beta concentrations decreased from 3.2 pg/microL to 1.9 pg/microL. Higher baseline IL-1beta concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1beta concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1beta concentrations. A strict Supra regimen reduced IL-1beta concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.</p>
},
	keywords = {*Biofilms, Adult, Dental Plaque/prevention \& control, Enzyme-Linked Immunosorbent Assay, Female, Gingival Crevicular Fluid/*chemistry, Humans, Interleukin-1beta/*analysis, Male, Middle Aged, Multivariate Analysis, Periodontal Index, Periodontitis/*microbiology/*therapy, Reference Values, Risk Factors, Smoking/*adverse effects, Time Factors},
	isbn = {1807-3107 (Electronic)1806-8324 (Linking)},
	url = {https://www.ncbi.nlm.nih.gov/pubmed/26892351},
	author = {Gomes, S. C. and Abascal, C. C. and Haas, A. N. and Angst, P. D. and Oppermann, R. V. and Marcantonio, R. A.}
}
