@article {6610, title = {Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross-sectional study}, journal = {Oral Dis}, volume = {26}, number = {2}, year = {2020}, note = {

Schutz, Jasper da Silvade Azambuja, Carolina BarreraCunha, Giuliano ReolonCavagni, JulianoRosing, Cassiano KuchenbeckerHaas, Alex NogueiraThome, Fernando SaldanhaFiorini, Tiagoeng150319/Hospital de Clinicas de Porto Alegre160428/Hospital de Clinicas de Porto AlegreDenmarkOral Dis. 2020 Mar;26(2):447-456. doi: 10.1111/odi.13236. Epub 2019 Dec 5.

}, month = {Mar}, pages = {447-456}, edition = {2019/11/20}, abstract = {

OBJECTIVE: The aim of this cross-sectional study was to evaluate the association between periodontitis and different severities of chronic kidney disease (CKD) in predialytic patients. MATERIALS AND METHODS: Demographic, socioeconomic, and medical data of 139 patients from the nephrology service of one university hospital in Porto Alegre, Brazil, were obtained through interview and clinical records. Full-mouth six-sites per tooth periodontal examinations were performed. Associations between periodontitis, stages of CKD, and estimated glomerular filtration rate (eGFR) were estimated by multivariable models adjusted for sex, smoking, vitamin D supplementation, physical activity, and renal treatment duration. CKD was classified based on eGFR (\<60 ml/min/1.73 m(2) ) estimated by the Chronic Kidney Disease Epidemiology Collaboration equation. RESULTS: Patients with severe periodontitis, compared to those without severe periodontitis, had 2.8 (95\% CI: 1.25-6.62) and 3.4 (95\% CI: 1.27-9.09) times higher risk of being in stages 4 and 5 of CKD, respectively. Having \>/= 2 teeth with clinical attachment loss (CAL) \>/=6 mm increased 3.9 times the risk of being in stage 5 of CKD. Patients with severe periodontitis and \>/=2 teeth with CAL \>/= 6 mm had 4.4 ml/min/1.73(2) and 5.2 ml/min/1.73(2) lower eGFR (p-values \< .05), respectively. CONCLUSION: Severe periodontitis was associated with poor renal conditions in predialytic CKD patients, strengthening the importance of periodontal evaluation in such patient population.

}, keywords = {Adult, Aged, Brazil, chronic kidney disease, chronic renal insufficiency, Cross-Sectional Studies, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, periodontitis, Periodontitis/*complications, Renal Insufficiency, Chronic/*complications, Risk Factors, Young Adult}, isbn = {1601-0825 (Electronic)1354-523X (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31742816}, author = {Schutz, J. D. S. and de Azambuja, C. B. and Cunha, G. R. and Cavagni, J. and Rosing, C. K. and Haas, A. N. and Thome, F. S. and Fiorini, T.} } @article {6609, title = {Survival of composite restorations after selective or total caries removal in primary teeth and predictors of failures: A 36-months randomized controlled trial}, journal = {J Dent}, volume = {93}, year = {2020}, note = {

Liberman, JFranzon, RGuimaraes, L FCasagrande, LHaas, A NAraujo, F BengEnglandJ Dent. 2020 Feb;93:103268. doi: 10.1016/j.jdent.2019.103268. Epub 2019 Dec 24.

}, month = {Feb}, pages = {103268}, edition = {2019/12/28}, abstract = {

OBJECTIVES: The aim of this study was to assess the survival of composite restorations after selective (SCR) or total caries removal (TCR) and determine predictors of failures after 36 months. METHODS: 120 teeth with deep occlusal or occlusal-proximal carious lesions were randomly divided into control (TCR; n = 54; 69\% Class II) and test (SCR; n = 66; 63\% Class II) groups. Clinical evaluation was applied using the USPHS criteria, and the presence of Charlie or Delta scores at the marginal integrity were considered as a failure. RESULTS: The overall survival rate of restorations was 68\% after 36 months, 81\% for TCR and 57\% for SCR (p = 0.004). The multivariable Cox Regression model demonstrated that restorations performed after SCR had 3.44 times greater probability of failure compared to TCR (p = 0.006). The other two predictors for failure of restorations were teeth with Class II cavities (hazard ratio = 3.3) and children with gingival bleeding over 20\% (hazard ratio = 2.5). CONCLUSIONS: Performing composite restorations after SCR in primary teeth had success rate significantly lower than restorations performed after TCR. Complex cavities and worst patient s oral hygiene were found to be predictors of failure of restorations. CLINICAL SIGNIFICANCE: Although SCR has been demonstrating high rates of pulp preservation, clinicians should consider that composite restorations fail in a higher frequency compared to TCR in primary teeth and, in some circumstances, may be preferable in terms of restoration longevity.

}, keywords = {*Composite resin, *Dental caries, *Longevity, *Primary teeth, *Selective caries removal, competing financial interests or personal relationships that could have appeared, to influence the work reported in this paper.}, isbn = {1879-176X (Electronic)0300-5712 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31881241}, author = {Liberman, J. and Franzon, R. and Guimaraes, L. F. and Casagrande, L. and Haas, A. N. and Araujo, F. B.} } @article {6606, title = {Periodontal status of individuals with Down syndrome: sociodemographic, behavioural and family perception influence}, journal = {J Intellect Disabil Res}, volume = {63}, number = {10}, year = {2019}, note = {

Nuernberg, M A AIvanaga, C AHaas, A NAranega, A MCasarin, R C VCaminaga, R M SGarcia, V GTheodoro, L HengObservational StudyEnglandJ Intellect Disabil Res. 2019 Oct;63(10):1181-1192. doi: 10.1111/jir.12629. Epub 2019 May 7.

}, month = {Oct}, pages = {1181-1192}, edition = {2019/05/08}, abstract = {

BACKGROUND: The aim of the present study was to assess the periodontal condition of individuals with Down syndrome and the association with sociodemographic and behavioural characteristics and family perception of oral health. METHODS: This cross-sectional observational study was performed at a referral centre for dental assistance to disabled persons in Aracatuba, Brazil. Parents of the individuals were interviewed, and the visible plaque index, bleeding on probing, probing pocket depth and clinical attachment level were recorded by one periodontist in six sites per tooth of all teeth. The individual was the unit of analysis. The significance level was set at 5\%. RESULTS: Sixty-four subjects (23.8 +/- 8.3 years old) were included. Eighteen (28.1\%) were diagnosed with gingivitis and 46 (71.9\%) with periodontitis. In the multiple logistic regression final model, age and self-reported oral hygiene practices were associated with the occurrence of periodontitis. The chance of having periodontitis was 4.7 times higher among individuals older than 20 years and approximately 4 times higher in patients whose oral hygiene was performed by themselves and their parents, compared with those who performed oral hygiene alone. Sex, follow-up time in the centre, education, degree of participants{\textquoteright} dependence, flossing and family history of periodontal disease were not associated with the occurrence of periodontitis. Higher levels of plaque and bleeding were observed for participants with parents reporting bad gingival health (76.2\% and 46.9\%) and deficient oral hygiene (79.5\% and 47.3\%). The perception of parents regarding gingival bleeding was correlated with higher bleeding detected clinically (P = 0.01; 50.1\%). CONCLUSIONS: The prevalence of periodontitis in individuals with Down syndrome is high and increases with age, even in the face of the parents{\textquoteright} perception about their children{\textquoteright}s oral condition.

}, keywords = {*Down syndrome, *health promotion, *periodontal diseases, Adolescent, Adult, Brazil/epidemiology, Comorbidity, Cross-Sectional Studies, Down Syndrome/*epidemiology, Female, Gingivitis/epidemiology, Humans, Male, Periodontal Diseases/*epidemiology, Periodontitis/epidemiology, Prevalence, Young Adult}, isbn = {1365-2788 (Electronic)0964-2633 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31062454}, author = {Nuernberg, M. A. A. and Ivanaga, C. A. and Haas, A. N. and Aranega, A. M. and Casarin, R. C. V. and Caminaga, R. M. S. and Garcia, V. G. and Theodoro, L. H.} } @article {6604, title = {Periodontitis and tooth loss have negative impact on dietary intake: A cross-sectional study with stable coronary artery disease patients}, journal = {J Periodontol}, volume = {90}, number = {10}, year = {2019}, note = {

Mendonca, Dayana DFurtado, Mariana VSarmento, Roberta ANicoletto, Bruna BSouza, Gabriela CWagner, Tassiane PChristofoli, Barbara RPolanczyk, Carisi AHaas, Alex NengResearch Support, Non-U.S. Gov{\textquoteright}tJ Periodontol. 2019 Oct;90(10):1096-1105. doi: 10.1002/JPER.19-0036. Epub 2019 May 27.

}, month = {Oct}, pages = {1096-1105}, edition = {2019/05/03}, abstract = {

BACKGROUND: Despite the association between cardiovascular diseases and periodontitis, there are scarce data on the impact of oral health in the dietary intake of patients with coronary artery disease (CAD). The aim of this study was to assess the association between dietary intake with periodontitis and present teeth in individuals with stable CAD. METHODS: This cross-sectional study included 115 patients with stable CAD (76 males, aged 61.0 +/- 8.3 years) who were under cardiovascular care in an outpatient clinic for at least 3 months. Dietary intake was recorded applying a food frequency questionnaire previously validated. Periodontal examinations were performed by two calibrated examiners in six sites per tooth from all present teeth. Blood samples were collected to determine serum levels of lipids. Multivariable logistic and linear regression models were fitted to evaluate the association between dietary outcomes and oral health variables. RESULTS: Individuals with periodontitis had significantly higher percentage of total energy intake from fried foods, sweets, and beans, and also had lower consumption of fruits than those without periodontitis. Presence of periodontitis was associated with lower percentage of individuals who reached the nutritional recommendation of monounsaturated fatty acids and higher blood concentration of triglycerides. Having a greater number of present teeth (\>/=20 teeth) was associated with higher intake of fibers and total calories. CONCLUSION: In patients with stable CAD, the presence of periodontitis and tooth loss were associated with a poor dietary intake of nutrients and healthy foods, which are important for cardiovascular prevention.

}, keywords = {*Coronary Artery Disease, *diet, *dyslipidemia, *Periodontitis, *Tooth Loss, Aged, Cross-Sectional Studies, Humans, Male, Middle Aged, Risk Factors}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31049952}, author = {Mendonca, D. D. and Furtado, M. V. and Sarmento, R. A. and Nicoletto, B. B. and Souza, G. C. and Wagner, T. P. and Christofoli, B. R. and Polanczyk, C. A. and Haas, A. N.} } @article {6603, title = {Occurrence and predictors of gingivitis and supragingival calculus in a population of Brazilian adults}, journal = {Braz Oral Res}, volume = {33}, year = {2019}, note = {

Haas, Alex NogueiraPrado, RenanRios, Fernando SilvaCosta, Ricardo Dos Santos AraujoAngst, Patricia Daniela MelchiorsMoura, Mauricio Dos SantosMaltz, MarisaJardim, Juliana JardimengBrazilBraz Oral Res. 2019 May 27;33:e036. doi: 10.1590/1807-3107bor-2019.vol33.0036.

}, month = {May 27}, pages = {e036}, edition = {2019/05/30}, abstract = {

The aim of this study was to determine the occurrence of gingivitis and calculus and their predictors in a population of adults in Brazil. A representative sample of 758 adults from 35 to 59 years of age from Porto Alegre city was examined. A structured questionnaire was applied. The Gingival Bleeding Index and the presence of calculus were measured at 4 sites/tooth. Multivariable logistic models were fitted to determine the predictors for gingival bleeding at \>20\% of sites. Overall, 96.5\% (95\% confidence interval [CI]=95.1-98.0) of individuals had \>/= 1 bleeding site. The mean percentages of sites with gingivitis and calculus were 26.1\% and 44.6\%, respectively. The odds of gingivitis decreased by approximately 45\% for individuals \>/=40 years old compared to younger adults. Individuals that never performed interproximal cleaning and non-whites had an approximately two times higher chance of gingivitis. Smokers had lower chances of gingivitis than never-smokers (odds ratio=0.40; 95\% CI=0.24-0.68). Higher numbers of missing teeth were associated with higher chances of gingivitis. The percentage of calculus was significantly associated with skin color, education, proximal cleaning, smoking exposure, dental visits, and tooth loss. It can be concluded that the occurrence of gingivitis and calculus was high in this Brazilian population, and it was associated with age, skin color, education, self-reported proximal cleaning, smoking, dental care, and tooth loss.

}, keywords = {Adult, Age Distribution, Brazil/epidemiology, Cross-Sectional Studies, Dental Calculus/*epidemiology/*etiology, Female, Gingival Hemorrhage/epidemiology, Gingivitis/*epidemiology/*etiology, Humans, Linear Models, Male, Middle Aged, Periodontal Index, Prevalence, Risk Factors, Sex Distribution, Smoking/adverse effects/epidemiology, Socioeconomic Factors, Toothbrushing/statistics \& numerical data}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31141035}, author = {Haas, A. N. and Prado, R. and Rios, F. S. and Costa, Rdsa and Angst, P. D. M. and Moura, M. D. S. and Maltz, M. and Jardim, J. J.} } @article {6605, title = {Randomized controlled trial of the effect of periodontal treatment on cardiovascular risk biomarkers in patients with stable coronary artery disease: Preliminary findings of 3 months}, journal = {J Clin Periodontol}, volume = {46}, number = {3}, year = {2019}, note = {

Montenegro, Marlon MRibeiro, Ingrid W JKampits, CassioSaffi, Marco A LFurtado, Mariana VPolanczyk, Carisi AHaas, Alex NRosing, Cassiano KengRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}tJ Clin Periodontol. 2019 Mar;46(3):321-331. doi: 10.1111/jcpe.13085. Epub 2019 Mar 6.

}, month = {Mar}, pages = {321-331}, edition = {2019/02/15}, abstract = {

AIM: To assess the effect of periodontal therapy (PT) on cardiovascular blood biomarkers. MATERIALS AND METHODS: This single-blind, parallel-design, randomized controlled trial included patients with stable coronary artery disease and periodontitis. The test group (TG) received non-surgical PT, whereas the control group (CG) received one session of plaque removal. Plasma levels of C-reactive protein (CRP), glycated haemoglobin, lipids and cytokines (IL-1beta, IL-6, IL-8, IL-10, IFN-gamma and TNF-alpha) were measured at baseline and after 3 months. RESULTS: Eighty-two patients (74.4\% women, mean age 59.6 years) were analysed. TG had significantly better periodontal parameters than CG after 3 months, but no significant differences in blood markers were observed between them. In a post hoc subgroup analysis in patients with baseline CRP \<3 mg/L, a significant increase in CRP was observed in CG (1.44 +/- 0.82 mg/L to 4.35 +/- 7.85 mg/L, p = 0.01), whereas CRP remained unchanged in TG (1.40 +/- 0.96 mg/L to 1.33 +/- 1.26 mg/L, p = 0.85), resulting in a significant difference between groups at 3 months. In patients with CRP \>/=3 mg/L, a significant reduction in CRP was observed only in TG (11.3 +/- 12.8 mg/L to 5.7 +/- 4.1 mg/L, p = 0.04). Levels of IL-6 and IL-8 were significantly lower in TG than CG at 3 months. CONCLUSIONS: PT leads to lower levels of CRP, IL-6 and IL-8 in cardiovascular patients with high CRP levels.

}, keywords = {*C-reactive protein, *cardiovascular disease, *Cardiovascular Diseases, *Coronary Artery Disease, *cytokines, *periodontal disease, Biomarkers, C-Reactive Protein, Female, Humans, Male, Middle Aged, Risk Factors, Single-Blind Method}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30761568}, author = {Montenegro, M. M. and Ribeiro, I. W. J. and Kampits, C. and Saffi, M. A. L. and Furtado, M. V. and Polanczyk, C. A. and Haas, A. N. and Rosing, C. K.} } @article {6602, title = {Validation of self-reported history of root canal treatment in a southern Brazilian subpopulation}, journal = {Braz Oral Res}, volume = {33}, year = {2019}, note = {

Franciscatto, Gisele JungKoppe, Barbara Thereza de FreitasHoppe, Carolina BenderOliveira, Joao Augusto Peixoto deHaas, Alex NogueiraGrecca, Fabiana SoaresRossi-Fedele, GiampieroGomes, Maximiliano SchunkeengObservational StudyValidation StudyBrazilBraz Oral Res. 2019 Feb 11;33:e007. doi: 10.1590/1807-3107bor-2019.vol33.0007.

}, month = {Feb 11}, pages = {e007}, edition = {2019/02/14}, abstract = {

The aim of this study was to assess self-reported history of root canal treatment (SRHRCT) as a method for detecting the presence of root canal treatment (RCT) and apical periodontitis (AP) in a southern Brazilian subpopulation. In this cross-sectional study, 136 military police officers from the city of Porto Alegre, Brazil, were included. The participants were interviewed and full-mouth periapical radiographs were taken. A calibrated examiner determined the presence of RCT and AP by applying standardized criteria. The diagnostic accuracy of SRHRCT was calculated separately for RCT and AP. Accuracy, sensitivity, specificity, positive and negative predictive values (+PV and -PV), efficiency, and positive and negative likelihood ratios (+LR and -LR) were estimated. The mean age of the participants was 34.1 +/- 10.4 years and 88.2\% were males. Overall, SRHRCT demonstrated high sensitivity and specificity for RCT, but not for AP: sensitivity (RCT = 0.960, AP = 0.757) and specificity (RCT = 0.835, AP = 0.631). The estimated values for PV and LR were: +PV (RCT=0.777, AP=0.396), -PV (RCT = 0.972, AP = 0.890), +LR (RCT = 5.853, AP = 2.057), and -LR (RCT = 0.046, AP = 0.383). SRHRCT proved to be a good predictor of the presence of RCT, but a weak predictor of AP in this subpopulation.

}, keywords = {Adult, Brazil/epidemiology, Cross-Sectional Studies, False Negative Reactions, False Positive Reactions, Female, Humans, Male, Middle Aged, Periapical Periodontitis/diagnostic imaging/*epidemiology, Prevalence, Radiography, Dental, Reference Values, Reproducibility of Results, Root Canal Therapy/*statistics \& numerical data, Self Report/*standards, Sensitivity and Specificity}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30758407}, author = {Franciscatto, G. J. and Koppe, B. T. F. and Hoppe, C. B. and Oliveira, J. A. P. and Haas, A. N. and Grecca, F. S. and Rossi-Fedele, G. and Gomes, M. S.} } @article {6601, title = {Predictors of dental plaque and gingivitis in patients receiving integrated dental treatment-a longitudinal retrospective study}, journal = {Clin Oral Investig}, volume = {23}, number = {2}, year = {2019}, note = {

Christofoli, Barbara RochaSilva, Natalia CaldeiraOliveira, Joao Augusto PeixotoFernandes, Marilene IssaHaas, Alex NogueiraengObservational StudyGermanyClin Oral Investig. 2019 Feb;23(2):651-659. doi: 10.1007/s00784-018-2485-z. Epub 2018 May 9.

}, month = {Feb}, pages = {651-659}, edition = {2018/05/10}, abstract = {

OBJECTIVES: The identification of predictors of supragingival biofilm accumulation may improve the results of therapeutic strategies for dental caries and periodontal diseases in general clinical practice. This study aimed to determine predictors of changes in visible plaque (VP) and gingival bleeding (GB) during integrated dental care. MATERIALS AND METHODS: A retrospective longitudinal study was conducted by a census of patients receiving integrated dental care in a general clinical practice ambulatory at the Federal University of Rio Grande do Sul (Brazil). The sample comprised 91 charts of patients attended over a 6-months period. Gender, age, patient{\textquoteright}s main complaint, oral hygiene pattern, and clinical data were recorded from charts for the last two dental visits in the ambulatory. Changes in VP and GB were modeled by multiple linear regression and beta coefficients (b) were reported. RESULTS: The mean follow-up time was 13 months. Significant reductions in VP (32.8 +/- 27.9 to 17.4 +/- 19.4\%; p \< 0.001) and GB (27.1 +/- 23.8 to 18.5 +/- 17.3\%; p \< 0.001) were observed. Higher plaque reductions were predicted by higher baseline VP levels (p = 0.02), shorter time (\< 12 months) elapsed between VP recordings (b = 14.1\%, p = 0.02), interproximal cleansing (b = 11.9\%, p = 0.03), lower number of sessions for oral hygiene instruction (b = 13.7\%, p = 0.02), and presence of pockets \>/= 6 mm (b = - 12.4\%, p = 0.02). GB was predicted by time of follow-up \> 12 months and baseline VP. CONCLUSIONS: Plaque and gingivitis improved in patients under integrated dental care. Factors related to motivation, oral hygiene practices, and baseline periodontal status might be used as predictors of VP and GB changes. CLINICAL RELEVANCE: Visible plaque and gingivitis reduced in a sample of patients treated under integrated dental care. Some predictors may determine for which patients the treatment may be maximize and those who will need greater efforts to achieve the therapeutic goal for oral hygiene.

}, keywords = {Brazil/epidemiology, Cohort study, Dental Care/*methods, Dental Plaque, Dental Plaque/epidemiology/*prevention \& control, Female, Gingivitis, Gingivitis/epidemiology/*prevention \& control, Humans, Longitudinal Studies, Male, Middle Aged, Oral Hygiene, Retrospective Studies, Risk Factors, Treatment Outcome}, isbn = {1436-3771 (Electronic)1432-6981 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29740720}, author = {Christofoli, B. R. and Silva, N. C. and Oliveira, J. A. P. and Fernandes, M. I. and Haas, A. N.} } @article {6608, title = {Self reported dentin hypersensitivity in south brazilian adolescents: occurrence and risk indicators}, journal = {Acta Odontol Latinoam}, volume = {32}, number = {3}, year = {2019}, note = {

Wagner, Tassiane PColussi, Paulo RHaas, Alex NRosing, Cassiano KengArgentinaActa Odontol Latinoam. 2019 Dec 1;32(3):156-163.

}, month = {Dec 1}, pages = {156-163}, edition = {2020/03/17}, abstract = {

The aim of this study was to assess the occurrence of selfreported dentin hypersensitivity (DH) and its risk indicators in adolescents from a southern Brazilian city. 736 students (1519 years old) were randomly selected from 20 public and private schools in the city of Passo Fundo, Brazil. DH was assessed through the answers on a Likert scale to the question: "Do you have tooth sensitivity?".Participants underwent a clinical examination in which present teeth were counted, and answered an interview based on a structured questionnaire on sociode mographic information, history of dental bleaching, orthodontic treatment and oral health habits. The dependent variable (DH) was dichotomized at the point where hypersen sitivity occurs fairly often or always. Data were analyzed by multivariable logistic regression, including demographic, health history, socioeconomic and behavioral variables. Results: 556 (75.5\%) subjects reported having sensitive teeth never, rarely or sometimes, while 180 (24.5\%) reported having sensitive teeth fairly often or always. In the final model, number of present teeth, age, skin color, flossing, smoking, bleaching and orthodontic history were not associated with selfreported DH. Females showed significantly greater chance of having DH than males [odds ratio (OR)=1.91; 95\% confidence interval (95\%CI) 1.342.72]. The likelihood of DH in students at public schools was 63\% higher than in those at private schools (OR=1.63 95\%, CI 1.012.75). DH is a common perception among adolescents and is associated with female gender and studying at public schools.

}, keywords = {Adolescent, Brazil/epidemiology, Cross-Sectional Studies, dentin sensitivity, Dentin Sensitivity/*epidemiology, Female, Humans, hypersensitivity, Male, Risk Factors, Self Report, Surveys and Questionnaires}, isbn = {1852-4834 (Electronic)0326-4815 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/32176239}, author = {Wagner, T. P. and Colussi, P. R. and Haas, A. N. and Rosing, C. K.} } @article {6607, title = {The impact of maintenance on peri-implant health}, journal = {Braz Oral Res}, volume = {33}, number = {suppl 1}, year = {2019}, note = {

Rosing, Cassiano KuchenbeckerFiorini, TiagoHaas, Alex NogueiraMuniz, Franciso Wilker Mustafa GomesOppermann, Rui VicenteSusin, CristianoengReviewBrazilBraz Oral Res. 2019 Sep 30;33(suppl 1):e074. doi: 10.1590/1807-3107bor-2019.vol33.0074. eCollection 2019.

}, pages = {e074}, edition = {2019/10/03}, abstract = {

Most of the literature evaluating dental implants focuses on implant survival, which is a limited proxy for the successful rehabilitation of patients with missing teeth. Success should include not only survival but also lack of mechanical, biological, and esthetics problems. A comprehensive review of local and systemic risk factors prior to implant placement will allow the tailoring of treatment planning and maintenance protocols to the patient{\textquoteright}s profile in order to achieve longitudinal success of the therapy. This review discusses the role of controlling different risk factors and prevention/treatment of peri-implant mucositis in order to avoid peri-implantitis. Although the literature addressing the topic is still scarce, the existing evidence shows that performing optimal plaque control and regular visits to the dentist seem to be adequate to prevent peri-implant lesions. Due to impossibility of defining a probing depth associate with peri-implant health, radiographic evaluations may be considered in the daily practice. So far, there is a strong evidence linking a past history of periodontal disease to peri-implant lesions, but this is not so evident for other factors including smoking and diabetes. The prevention of biological complications starts even before implant placement and include a broader analysis of the patient risk profile and tailoring the rehabilitation and maintenance protocols accordingly. It should be highlighted that the installation of implants does not modify the patient profile, since it does not modify genetics, microbiology or behavioral habits of any individual.

}, keywords = {*Bone-Implant Interface/diagnostic imaging, Dental Implants/*adverse effects, Dental Plaque/prevention \& control, Humans, Oral Hygiene, Peri-Implantitis/etiology/*prevention \& control, Periodontal Index, Periodontitis/etiology/*prevention \& control, Radiography, Dental, Risk Factors, Stomatitis/etiology/*prevention \& control}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31576958}, author = {Rosing, C. K. and Fiorini, T. and Haas, A. N. and Muniz, Fwmg and Oppermann, R. V. and Susin, C.} } @article {6598, title = {Occurrence of peri-implant diseases and risk indicators at the patient and implant levels: A multilevel cross-sectional study}, journal = {J Periodontol}, volume = {89}, number = {9}, year = {2018}, note = {

Pimentel, Suzana PShiota, RobertoCirano, Fabiano RCasarin, Renato C VPecorari, Vanessa G ACasati, Marcio ZHaas, Alex NRibeiro, Fernanda VengJ Periodontol. 2018 Sep;89(9):1091-1100. doi: 10.1002/JPER.17-0599. Epub 2018 Aug 8.

}, month = {Sep}, pages = {1091-1100}, edition = {2018/05/16}, abstract = {

BACKGROUND: High prevalence rates of peri-implant diseases have been reported; however, the lack of standardization of definition criteria has lead to variations in the observed estimates. In addition, scarce data are available concerning patient and implant related factors associated to peri-implantitis. The aim of this study was to determine the prevalence of peri-implant diseases and their risk indicators at the patient and implant levels. METHODS: One hundred forty-seven patients with 490 dental implants were included. Dental implants were clinically and radiographically evaluated to determine their peri-implant conditions. Patient-related conditions and implant and prosthetic-related factors were recorded. Multivariable Poisson regression was fitted and prevalence ratios (PR) were reported. RESULTS: 85.3\% of implants (95\%CI 80.2 to 90.4) had mucositis and 9.2\% (95\%CI 4.7 to 13.7) had peri-implantitis. 80.9\% (95\%CI 73.8 to 86.8), and 19.1\% (95\%CI 12.6 to 25.5) of patients had mucositis and peri-implantitis. At the patient level, it was observed an increased probability of peri-implantitis in individuals with pocket depths \>/=6 mm (PR = 2.47) and with \>/=4 implants (PR = 1.96). Smoking increased the probability of peri-implantitis by three times (PR = 3.49). The final multilevel Poisson regression model at the implant level indicated that platform switching reduced the probability of peri-implantitis (PR = 0.18) and implants in function for \>/=5 years increased this probability (PR = 2.11). The final model including patient and implant level indicators demonstrated that higher time of function (PR = 2.76) and smoking (PR = 6.59) were associated with peri-implantitis. CONCLUSION: Peri-implant diseases are highly prevalent in the studied sample, and factors associated with the occurrence of peri-implantitis were presence of pockets \>/=6 mm, smoking, time of function, and type of platform.

}, keywords = {*cross-sectional studies, *Dental Implants, *Mucositis, *Peri-Implantitis, *risk factors, *Stomatitis, Cross-Sectional Studies, Humans, Risk Factors}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29761866}, author = {Pimentel, S. P. and Shiota, R. and Cirano, F. R. and Casarin, R. C. V. and Pecorari, V. G. A. and Casati, M. Z. and Haas, A. N. and Ribeiro, F. V.} } @article {6600, title = {Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial}, journal = {Oral Dis}, volume = {24}, number = {7}, year = {2018}, note = {

Saffi, Marco Aurelio LRabelo-Silva, Eneida RPolanczyk, Carisi AFurtado, Mariana VMontenegro, Marlon MRibeiro, Ingrid W JKampits, CassioRosing, Cassiano KHaas, Alex NengCNPq 476387/2010-8/Brazilian Ministry of Science and TechnologyFAPERGS 1008214/Research Support Agency from Rio Grande do Sul StateRandomized Controlled TrialDenmarkOral Dis. 2018 Oct;24(7):1349-1357. doi: 10.1111/odi.12909. Epub 2018 Jul 10.

}, month = {Oct}, pages = {1349-1357}, edition = {2018/06/07}, abstract = {

OBJECTIVE: To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease. MATERIALS AND METHODS: A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received nonsurgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling, and root planing per quadrant, whereas the control group received equal treatment after the study period. Endothelial function was assessed by measurement of brachial artery flow-mediated dilation, concentrations of sVCAM-1, sICAM-1, and P-selectin in serum before and 3 months after periodontal therapy. RESULTS: The test group exhibited statistically better periodontal parameters-plaque, probing depth, periodontal attachment loss, and bleeding on probing. No significant improvements were observed in the control (1.37\%) and test (1.39\%) groups in flow-mediated dilation, with no significant between-group difference. sVCAM-1 concentration increased in the control group (997.6 +/- 384.4-1201.8 +/- 412.5; p = 0.03), whereas in the test group, no significant changes were observed (915.1 +/- 303.8-1050.3 +/- 492.3; p = 0.17), resulting in a significant difference between the two groups (p = 0.04). The same pattern was observed for concentrations of sICAM-1. CONCLUSION: Periodontal treatment did not provide better vasodilation in patients with coronary disease in a short-term follow-up period, although it maintained blood concentrations of markers of vascular inflammation.

}, keywords = {Aged, Atherosclerosis, Coronary Artery Disease/complications/*physiopathology, Endothelium, Vascular/*physiopathology, Female, flow-mediated dilation, Humans, Intercellular Adhesion Molecule-1/blood, Male, Middle Aged, Oral Hygiene, P-Selectin/blood, Patient Education as Topic, periodontitis, Periodontitis/complications/*therapy, Root Planing, Single-Blind Method, Vascular Cell Adhesion Molecule-1/blood, vascular endothelium, Vasodilation/physiology}, isbn = {1601-0825 (Electronic)1354-523X (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29873864}, author = {Saffi, M. A. L. and Rabelo-Silva, E. R. and Polanczyk, C. A. and Furtado, M. V. and Montenegro, M. M. and Ribeiro, I. W. J. and Kampits, C. and Rosing, C. K. and Haas, A. N.} } @article {6599, title = {Vitamin D levels and risk for periodontal disease: A systematic review}, journal = {J Periodontal Res}, volume = {53}, number = {3}, year = {2018}, note = {

Pinto, J P N SGoergen, JMuniz, F W M GHaas, A NengSystematic ReviewJ Periodontal Res. 2018 Jun;53(3):298-305. doi: 10.1111/jre.12531. Epub 2018 Mar 1.

}, month = {Jun}, pages = {298-305}, edition = {2018/03/02}, abstract = {

OBJECTIVE: To evaluate the existing evidence supporting or refuting the following questions: (i) Do patients with lower vitamin D levels have higher risk for periodontal disease? (ii) Are periodontal treatment outcomes improved by the adjuvant supplementation of vitamin D or by elevated serum vitamin D levels? MATERIAL AND METHODS: MEDLINE, SCOPUS, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched up to September 2017. Studies were included if they had measured serum vitamin D levels or vitamin D intake and any periodontal parameter. RESULTS: Overall, 27 studies were included (13 cross-sectional studies, 6 case-control studies, 5 cohort studies, 2 randomized clinical trials and 1 case series study). Sixty-five percent of the cross-sectional studies reported significant associations between low vitamin D levels and poor periodontal parameters. None of the observational longitudinal studies found that periodontal disease progression could be attributed to lower vitamin D levels. No interventional studies that evaluated the use of vitamin D supplementation as a solely adjuvant to periodontal treatment was found. No meta-analysis was performed due to high variability across studies. CONCLUSION: The data to support or refute the association between vitamin D levels and periodontal disease are inconclusive at the moment. More rigorously designed longitudinal studies with standardized definitions of periodontal disease and vitamin D are necessary.

}, keywords = {Databases, Factual, Dietary Supplements, epidemiology, Humans, periodontal disease, Periodontal Diseases/*blood/epidemiology/etiology, Randomized Controlled Trials as Topic, Risk Factors, systematic review, vitamin D, Vitamin D/administration \& dosage/*blood}, isbn = {1600-0765 (Electronic)0022-3484 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29492977}, author = {Pinto, Jpns and Goergen, J. and Muniz, Fwmg and Haas, A. N.} } @article {6595, title = {Influence of Periodontal Disease on Changes of Glycated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus: A Retrospective Cohort Study}, journal = {J Periodontol}, volume = {88}, number = {1}, year = {2017}, note = {

Costa, Katia LTaboza, Zuila AAngelino, Gisele BSilveira, Virginia RMontenegro, Renan JrHaas, Alex NRego, Rodrigo OengResearch Support, Non-U.S. Gov{\textquoteright}tJ Periodontol. 2017 Jan;88(1):17-25. doi: 10.1902/jop.2016.160140. Epub 2016 Aug 26.

}, month = {Jan}, pages = {17-25}, edition = {2016/08/27}, abstract = {

BACKGROUND: Little evidence is available regarding the effects of long-term periodontal infection on diabetes mellitus (DM) control. The aim of this retrospective cohort study is to evaluate influence of periodontal status on changes of glycated hemoglobin (HbA1c) levels of patients with type 2 DM (DMt2). METHODS: Eighty patients (mean age: 56.0 +/- 8.9 years) with DMt2 were included. Patients were non-smokers, aged \>/=40 years, and using antidiabetic drugs. Demographics, health history, and HbA1c levels were retrieved from medical charts. Probing depth and clinical attachment loss (AL) were recorded. RESULTS: Patients were examined at two time points within a mean interval of 38.6 +/- 6.6 months. Increase in HbA1c over time was statistically significant when severe periodontitis was diagnosed at baseline (2.32\%, 95\% confidence interval [CI]: 1.50\% to 3.15\%), in patients showing at least one tooth with \>/=2 mm of AL progression (2.24\%, 95\% CI: 1.56\% to 2.91\%), in males (2.75\%, 95\% CI: 1.72\% to 3.78\%), and in those with HbA1c \<6.5\% at baseline (3.08\%, 95\% CI: 2.47\% to 3.69\%). After adjusting for baseline HbA1c, significant changes were still observed for severe periodontitis and progression of AL with increases of 0.85\% and 0.9\%, respectively. After adjusting for sex and HbA1c, AL progression was also statistically significant, with increases of 0.84\%. CONCLUSIONS: Periodontitis progression was associated with increase in HbA1c in patients with DMt2. Identification of these risk factors suggests that periodontal treatment may improve glycemic control of patients with DMt2 by eliminating periodontal infection.

}, keywords = {*Diabetes mellitus, type 2, *hyperglycemia, *Periodontitis, Adult, Aged, Diabetes Mellitus, Type 2/*blood/*complications, Disease Progression, Female, Glycated Hemoglobin A/*metabolism, Humans, Male, Middle Aged, Periodontal Diseases/*blood/*complications, Periodontal Index, Retrospective Studies}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27562220}, author = {Costa, K. L. and Taboza, Z. A. and Angelino, G. B. and Silveira, V. R. and Montenegro, R., Jr. and Haas, A. N. and Rego, R. O.} } @article {6597, title = {Effect of Alcohol Consumption on Clinical Attachment Loss Progression in an Urban Population From South Brazil: A 5-Year Longitudinal Study}, journal = {J Periodontol}, volume = {88}, number = {12}, year = {2017}, note = {

Wagner, Marcius CHaas, Alex NOppermann, Rui VRosing, Cassiano KAlbandar, Jasim MSusin, CristianoengResearch Support, Non-U.S. Gov{\textquoteright}tJ Periodontol. 2017 Dec;88(12):1271-1280. doi: 10.1902/jop.2017.170231. Epub 2017 Jul 28.

}, month = {Dec}, pages = {1271-1280}, edition = {2017/07/29}, abstract = {

BACKGROUND: The aim of this study is to investigate the impact of alcohol consumption on clinical attachment loss (AL) progression over a period of 5 years. METHODS: A multistage probability sampling strategy was used to draw a representative sample of the metropolitan area of Porto Alegre, Brazil. Five hundred thirty-two individuals (209 males and 293 females) aged 18 to 65 years at baseline with no medical history of diabetes and at least six teeth were included in this analysis. Full-mouth periodontal examinations with six sites per tooth were conducted at baseline and after 5 years. Alcohol consumption was assessed at baseline by asking participants about the usual number of drinks consumed in a week. Four categories of alcohol consumption were defined: 1) non-drinker; 2) 1 glass/week and 1 glass/day. Individuals showing at least two teeth with proximal (clinical AL) progression \>/=3 mm over 5 years were classified as having disease progression. Multiple Poisson regression models adjusted for age, sex, smoking, socioeconomic status, and body mass index were used to estimate relative risks (RRs) and 95\% confidence intervals (CIs). RESULTS: Overall, individuals who consumed \>1 glass/day had 30\% higher risk for clinical AL progression (RR = 1.30; 95\% CI: 1.07 to 1.58) than non-drinkers. Among males, risk of clinical AL progression for individuals drinking \>1 glass/day was 34\% higher than non-drinkers (RR = 1.34; 95\% CI: 1.09 to 1.64). Never-smoker males drinking 1 glass/day had significantly higher risk (RR = 1.50; 95\% CI: 1.08 to 1.99). Among females, no association between alcohol consumption and clinical AL progression was observed. CONCLUSIONS: Alcohol consumption increased the risk of clinical AL progression, and this effect was more pronounced in males. Low dosages (

}, keywords = {*Alcohol drinking, *epidemiology, *longitudinal studies, *Periodontitis, *risk factors, Adolescent, Adult, Age Factors, Aged, Alcohol Drinking/*adverse effects/epidemiology, Body Mass Index, Brazil/epidemiology, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Periodontal Attachment Loss/*epidemiology/etiology, Poisson Distribution, Risk, Risk Factors, Sex Factors, Smoking/adverse effects, Socioeconomic Factors, Urban Population/statistics \& numerical data, Young Adult}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/28753103}, author = {Wagner, M. C. and Haas, A. N. and Oppermann, R. V. and Rosing, C. K. and Albandar, J. M. and Susin, C.} } @article {6596, title = {Association between chronic oral inflammatory burden and physical fitness in males: a cross-sectional observational study}, journal = {Int Endod J}, volume = {50}, number = {8}, year = {2017}, note = {

Hoppe, C BOliveira, J A PGrecca, F SHaas, A NGomes, M SengObservational StudyEnglandInt Endod J. 2017 Aug;50(8):740-749. doi: 10.1111/iej.12686. Epub 2016 Oct 5.

}, month = {Aug}, pages = {740-749}, edition = {2016/09/01}, abstract = {

AIM: To evaluate the association between chronic oral inflammatory burden (OIB) - as the combination of periodontal and endodontic disease load - and physical fitness. METHODOLOGY: One hundred and twelve nonsmoker male police officers who performed a standardized physical fitness test (PFT) were analysed. Participants underwent oral clinical and periapical radiographic examinations. Periodontal disease was assessed by probing depth (PD) and clinical attachment loss (AL). For radiographic analysis, both apical periodontitis (AP) and root canal treatment (RCT) variables were analysed. Endodontic Burden (EB) was calculated merging the total number of teeth with AP and/or RCT per individual. OIB was calculated combining EB and AL. The outcome of physical fitness was dichotomized according to whether the highest PFT score was {\textquoteright}achieved{\textquoteright} or {\textquoteright}not-achieved{\textquoteright}. Multivariable logistic regression models were adjusted for age, body mass index and frequency of daily exercise. RESULTS: There was no significant association between AP, RCT and EB with physical fitness whereas PD, AL and OIB were significantly associated with low physical fitness (P \< 0.05). Multivariate regression analysis revealed that individuals with OIB = EB \>/= 3 and AL \>/= 4 mm had a 81\% lower chance of reaching the highest PFT score (OR = 0.19, 95\%CI = 0.04-0.87, P = 0.03) compared to individuals with EB \< 3 and and no AL \>/= 4 mm. Individuals with unfavourable periodontal parameters but with low EB (OIB = EB \< 3 \& AL \>/= 4 mm) showed no significant differences on the chance to reach the highest PFT score compared to participants with favourable periodontal status and low EB (OIB = EB \< 3 \& no AL \>/= 4 mm). CONCLUSIONS: The OIB - higher levels of EB in periodontal patients - was independently associated with poor physical fitness in males.

}, keywords = {*Periodontal Index, Adult, apical periodontitis, Cross-Sectional Studies, Humans, Male, oral-systemic diseases, Periapical Periodontitis/*physiopathology/surgery, periodontal disease, Periodontal Diseases/*physiopathology/surgery, physical fitness, Physical Fitness/*physiology, Risk Factors, Root Canal Therapy, Young Adult}, isbn = {1365-2591 (Electronic)0143-2885 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27578486}, author = {Hoppe, C. B. and Oliveira, J. A. P. and Grecca, F. S. and Haas, A. N. and Gomes, M. S.} } @article {6587, title = {Predictors of clinical outcomes after periodontal treatment of aggressive periodontitis: 12-month randomized trial}, journal = {Braz Oral Res}, volume = {30}, number = {1}, year = {2016}, note = {

Haas, Alex NogueiraSilva-Boghossian, Carina MacielColombo, Ana PaulaAlbandar, JasimOppermann, Rui VicenteRosing, Cassiano KuchenbeckerSusin, CristianoengRandomized Controlled TrialBrazilBraz Oral Res. 2016 May 20;30(1). pii: S1806-83242016000100245. doi: 10.1590/1807-3107BOR-2016.vol30.0041.

}, month = {May 20}, edition = {2016/05/26}, abstract = {

Little is known about the factors that may be used in clinical practice to predict the therapeutic response of aggressive periodontitis patients. The aim of this study was to determine predictors of clinical outcomes after non-surgical treatment of aggressive periodontitis. A total of 24 patients (aged 13-26 years) received oral hygiene instructions, as well as subgingival scaling and root planing. Twelve subjects received systemic azithromycin at random. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. Baseline microbiological assessment was performed by checkerboard DNA-DNA hybridization. Multivariable models used generalized estimating equations. There were significant improvements in the entire sample in regard to pocket depth, clinical attachment level and bleeding on probing. Significant predictors of a reduction in mean pocket depth were: use of azithromycin, non-molar teeth, generalized disease and baseline pocket depth. Absence of plaque predicted a 0.22 mm higher attachment gain, whereas a baseline pocket depth \>/=7 mm predicted a 1.36 mm higher attachment loss. Azithromycin, plaque, and baseline pocket depth were significant predictors of bleeding on probing. The concomitant presence of all three red complex species predicted a 0.78 mm higher attachment loss. It may be concluded that dental plaque, tooth type, disease extent, baseline pocket depth, and use of azithromycin were significant predictors of the clinical response to treatment for aggressive periodontitis in young individuals. Moreover, the presence of multiple periodontal pathogens may predict challenges in achieving a favorable outcome for aggressive periodontitis.

}, keywords = {Adolescent, Adult, Aggressive Periodontitis/*therapy, Anti-Bacterial Agents/therapeutic use, Azithromycin/therapeutic use, Dental Plaque/microbiology, Dental Scaling/*methods, Female, Humans, Male, Multivariate Analysis, Oral Hygiene/*methods, Periodontal Index, Periodontium/microbiology, Root Planing/*methods, Time Factors, Treatment Outcome, Young Adult}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27223128}, author = {Haas, A. N. and Silva-Boghossian, C. M. and Colombo, A. P. and Albandar, J. and Oppermann, R. V. and Rosing, C. K. and Susin, C.} } @article {6589, title = {Periodontal disease and inflammatory blood cytokines in patients with stable coronary artery disease}, journal = {J Appl Oral Sci}, volume = {24}, number = {4}, year = {2016}, note = {

Kampits, CassioMontenegro, Marlon MRibeiro, Ingrid W JFurtado, Mariana VPolanczyk, Carisi ARosing, Cassiano KHaas, Alex NengBrazilJ Appl Oral Sci. 2016 Jul-Aug;24(4):352-8. doi: 10.1590/1678-775720160082.

}, month = {Jul-Aug}, pages = {352-8}, edition = {2016/08/25}, abstract = {

MATERIAL AND METHODS: This cross-sectional study included 91 patients with stable CAD who had been under optimized cardiovascular care. Blood levels of IL-1beta, IL-6, IL-8, IL-10, IFN-gamma, and TNF-alpha were measured by Luminex technology. A full-mouth periodontal examination was conducted to record probing depth (PD) and clinical attachment (CA) loss. Multiple linear regression models, adjusting for gender, body mass index, oral hypoglycemic drugs, smoking, and occurre:nce of acute myocardial infarction were applied. RESULTS: CAD patients that experienced major events had higher concentrations of IFN-gamma (median: 5.05 pg/mL vs. 3.01 pg/mL; p=0.01), IL-10 (median: 2.33 pg/mL vs. 1.01 pg/mL; p=0.03), and TNF-alpha (median: 9.17 pg/mL vs. 7.47 pg/mL; p=0.02). Higher numbers of teeth with at least 6 mm of CA loss (R2=0.07) and PD (R2=0.06) were significantly associated with higher IFN-gamma log concentrations. Mean CA loss (R2=0.05) and PD (R2=0.06) were significantly related to IL-10 concentrations. Elevated concentrations of TNF-alpha were associated with higher mean CA loss (R2=0.07). CONCLUSION: Periodontal disease is associated with increased systemic inflammation in stable cardiovascular patients. These findings provide additional evidence supporting the idea that periodontal disease can be a prognostic factor in cardiovascular patients.

}, keywords = {Aged, Biomarkers/blood, Coronary Artery Disease/*blood/physiopathology, Cross-Sectional Studies, Female, Humans, Interferon-gamma/*blood, Interleukins/*blood, Linear Models, Male, Middle Aged, Periodontal Attachment Loss, Periodontal Diseases/*blood/physiopathology, Periodontal Index, Predictive Value of Tests, Reference Values, Risk Factors, Smoking/adverse effects, Surveys and Questionnaires, Tumor Necrosis Factor-alpha/*blood}, isbn = {1678-7765 (Electronic)1678-7757 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27556206}, author = {Kampits, C. and Montenegro, M. M. and Ribeiro, I. W. and Furtado, M. V. and Polanczyk, C. A. and Rosing, C. K. and Haas, A. N.} } @article {6586, title = {Effect of obesity on periodontal attachment loss progression: a 5-year population-based prospective study}, journal = {J Clin Periodontol}, volume = {43}, number = {7}, year = {2016}, note = {

Gaio, Eduardo JoseHaas, Alex NogueiraRosing, Cassiano KuchenbeckerOppermann, Rui VicenteAlbandar, Jasim MSusin, CristianoengJ Clin Periodontol. 2016 Jul;43(7):557-65. doi: 10.1111/jcpe.12544. Epub 2016 May 19.

}, month = {Jul}, pages = {557-65}, edition = {2016/03/13}, abstract = {

AIM: The aim of this study was to assess the effect of overweight and obesity on periodontal attachment loss (PAL) progression in an urban population from south Brazil. METHODS: In 2001, a population-based oral health survey entitled "Epidemiology of periodontal diseases: the Porto Alegre Study" was conducted by drawing a probabilistic sample of 1586 individuals. After 5 years, 755 (participation rate: 47.6\%) individuals were re-examined. For this analysis, self-reported diabetics, underweight individuals, and individuals with \<6 teeth were excluded. Poisson regressions were used to calculate relative risks (RR) and 95\% confidence intervals (CI) adjusted for sex, age, skin colour, education, socio-economic status, smoking and dental care. RESULTS: Five hundred and eighty-two individuals (333 males/249 females, 36.02 +/- 14.97 years) were included. Overall, obese individuals had significantly higher risk of experiencing PAL progression than individuals with normal weight after adjusting for important co-factors (RR = 1.36, 95\% CI = 1.04-1.78). In a stratified analysis, no statistically significant associations were observed between PAL progression and obesity for males (RR = 1.13, 95\% CI = 0.75-1.69), whereas obese females were at statistically significant higher risk than normal weight females (RR = 1.64, 95\% CI = 1.11-2.43). CONCLUSION: Obesity appears to be a risk factor for PAL progression for females but not males in this developing country population.

}, keywords = {*epidemiology, *longitudinal studies, *Obesity, *Periodontal Attachment Loss, *Periodontitis, Adult, Brazil, Female, Humans, Male, Prospective Studies}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26970086}, author = {Gaio, E. J. and Haas, A. N. and Rosing, C. K. and Oppermann, R. V. and Albandar, J. M. and Susin, C.} } @article {6588, title = {Essential oils-containing mouthwashes for gingivitis and plaque: Meta-analyses and meta-regression}, journal = {J Dent}, volume = {55}, year = {2016}, note = {

Haas, Alex NogueiraWagner, Tassiane PantaMuniz, Francisco Wilker Mustafa GomesFiorini, TiagoCavagni, JulianoCeleste, Roger KellerengMeta-AnalysisReviewEnglandJ Dent. 2016 Dec;55:7-15. doi: 10.1016/j.jdent.2016.09.001. Epub 2016 Sep 11.

}, month = {Dec}, pages = {7-15}, edition = {2016/09/16}, abstract = {

OBJECTIVES: To evaluate the efficacy of EO as adjuncts to mechanical plaque control (MPC) on the reduction of plaque and gingivitis when compared to placebo or cetylpyridium chloride (CPC). DATA: Randomized controlled trials of at least 6 months of follow-up including systemically healthy individuals with gingivitis were included. SOURCES: MEDLINE, EMBASE, Lilacs and SCOPUS were searched up to April 2016. From 3045 citations, 16 studies were included. 14 studies assessed the Quigley-Hein Plaque Index (QHI) and 11 studies assessed the Modified Gingival Index (MGI) and were included in meta-analyses and meta-regression. STUDY SELECTION: The analysis of risk of bias suggested that the quality of the studies ranged from moderate to low. Mean QHI (WMD=-0.86, 95\%CI -1.05 to -0.66) and MGI (WMD=-0.52, 95\%CI -0.67 to -0.37) were lower for EO+MPC than placebo+MPC. Reductions in plaque and gingivitis were, respectively, 32\% and 24\% larger for EO+MPC than placebo+MPC. The decreases in QHI (WMD=-0.95, 95\%CI -1.26 to -0.63) and in MGI (WMD=-0.34, 95\%CI -0.53 to -0.15) observed in the EO+MPC group, compared to placebo+MPC in interproximal areas, were significantly different and in favor to EO+MPC. EO+MPC compared to CPC+MPC resulted in clinically lower levels of plaque and gingivitis. High heterogeneity (I(2)\>95\%) was found and explained (MGI-R(2)=63.6\%; QHI-R(2)=80.1\%) by differences between studies in the percentage of males, supervision of the mouthwashes and provision of oral hygiene. CONCLUSIONS: EO seems to be superior to placebo+MPC and CPC+MPC for reduction of plaque and gingival inflammation in patients with gingivitis. Expected benefits may be clinically relevant and may also reach the interproximal area. CLINICAL SIGNIFICANCE: Mouthwashes containing essential oils should be considered the first choice for daily use as adjuvants to self-performed mechanical plaque control.

}, keywords = {*Cetylpyridinium, *Dental plaque, *Essential oils, *Gingivitis, *Meta-analysis, *Mouthwashes, Anti-Infective Agents, Local, Dental Plaque, Dental Plaque Index, Gingivitis, Humans, Male, Oils, Volatile, Periodontal Index}, isbn = {1879-176X (Electronic)0300-5712 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27628316}, author = {Haas, A. N. and Wagner, T. P. and Muniz, Fwmg and Fiorini, T. and Cavagni, J. and Celeste, R. K.} } @article {6591, title = {Agreement between clinical and histopathologic diagnoses and completeness of oral biopsy forms}, journal = {Braz Oral Res}, volume = {30}, number = {1}, year = {2016}, note = {

Mendez, MarinaHaas, Alex NogueiraRados, Pantelis VarvakiSant{\textquoteright}ana, Manoel FilhoCarrard, Vinicius CoelhoengBrazilBraz Oral Res. 2016 Aug 22;30(1):e94. doi: 10.1590/1807-3107BOR-2016.vol30.0094.

}, month = {Aug 22}, pages = {e94}, edition = {2016/08/25}, abstract = {

The present study aimed to assess the rate of agreement between clinical and histopathological diagnoses and to report the frequency of completed forms for specimens that were subjected to histopathological examination and retrospectively examined. Data from 8,168 specimens submitted to histopathological examination were retrieved from the records. A total of 5,368 cases were included. Agreement was defined based on the definition of lesion nature according to its diagnostic category. Sensitivity, specificity, and positive and negative predictive values were calculated for each diagnostic category. The highest rate of agreement was observed for periapical lesions (92.6\%), followed by potentially malignant disorders (90.1\%) and non-neoplastic proliferative disorders (89.3\%). Low rates of histopathological confirmation of the clinical impression were observed for mesenchymal tumors (25.0\%) and cysts (44.2\%). Sensitivity values were \> 0.70 for all lesions, except for cysts (0.51). Specificity was relatively high, ranging from 0.97 to 1.00. The frequency of incomplete biopsy forms ranged from 16.8\% (malignant tumors of oral mucosal epithelium) to 51.0\% (nonspecific inflammatory reaction). The most frequently completed biopsy forms corresponded to epithelial malignant tumors (83.2\%) and glandular inflammation (72.3\%). In conclusion, there was an acceptable level of agreement. The low level of completeness of biopsy forms indicates little awareness about the relevance of gathering detailed information during clinical examination.

}, keywords = {Biopsy/methods, Diagnostic Errors, Female, Humans, Male, Mouth Diseases/*pathology, Mouth Mucosa/pathology, Mouth/*pathology, Reference Values, Retrospective Studies, Sensitivity and Specificity}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27556681}, author = {Mendez, M. and Haas, A. N. and Rados, P. V. and Sant{\textquoteright}ana, M. Filho and Carrard, V. C.} } @article {6592, title = {Self-reported halitosis and associated demographic and behavioral factors}, journal = {Braz Oral Res}, volume = {30}, number = {1}, year = {2016}, note = {

Milanesi, Fernanda CarpesKauer, BrunoWagner, Tassiane PantaDaudt, Luciana DondonisHaas, Alex NogueiraengBrazilBraz Oral Res. 2016 Aug 22;30(1):e71. doi: 10.1590/1807-3107BOR-2016.vol30.0071.

}, month = {Aug 22}, pages = {e71}, edition = {2016/08/25}, abstract = {

Halitosis is still poorly studied in young adults. The aim of this study was to evaluate the occurrence of self-reported halitosis and associate it with demographic and behavioral factors in young adult dental students. This cross-sectional study was designed as a census of students enrolled in three initial and three final semesters of a dental course in a Brazilian public university. Of 284 eligible students, 257 (90.5\%) completed a self-administered questionnaire. Self-reported halitosis was the primary study outcome, and was assessed with the question "do you feel you have bad breath?". Data on age, gender, frequency of tooth brushing and interproximal cleaning, tongue cleaning, mouth rinse use and dry mouth were collected using the questionnaire, and were considered independent variables. Of the students surveyed, 26.5\% reported as never, 51.7\% as rarely, 21.4\% as sometimes, and 0.4\% as always feeling they had halitosis. Morning halitosis was reported by 90.6\% of those who reported halitosis. In the final multiple model, last semester students had a 55\% lower chance of reporting halitosis, compared with students from the first semesters [odds ratio (OR) 0.46; 95\%CI 0.24-0.89]. Women had a 2.57fold higher chance of reporting halitosis (OR = 2.57; 95\%CI 1.12-5.93). Dry mouth increased the chance of self-reported halitosis 3.95-fold, compared with absence of dry mouth (OR = 3.95; 95\%CI 2.03-7.68). It can be concluded that self-reports of halitosis were low among dental students, but may represent an important complaint. Gender, dry mouth and level of college education of the dentist were factors significantly associated with self-reported halitosis.

}, keywords = {*Self Report, Adolescent, Adult, Age Distribution, Brazil/epidemiology, Demography, Epidemiologic Methods, Female, Halitosis/*epidemiology/etiology, Humans, Male, Oral Hygiene/statistics \& numerical data, Sex Distribution, Students, Dental/*statistics \& numerical data, Time Factors, Young Adult}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/27556677}, author = {Milanesi, F. C. and Kauer, B. and Wagner, T. P. and Daudt, L. D. and Haas, A. N.} } @article {6593, title = {Gingival recession and oral health-related quality of life: a population-based cross-sectional study in Brazil}, journal = {Community Dent Oral Epidemiol}, volume = {44}, number = {4}, year = {2016}, note = {

Wagner, Tassiane PCosta, Ricardo S ARios, Fernando SMoura, Mauricio SMaltz, MarisaJardim, Juliana JHaas, Alex NengDenmarkCommunity Dent Oral Epidemiol. 2016 Aug;44(4):390-9. doi: 10.1111/cdoe.12226. Epub 2016 Mar 8.

}, month = {Aug}, pages = {390-9}, edition = {2016/03/10}, abstract = {

OBJECTIVES: To assess the association between gingival recession (GR) and oral health-related quality of life (OHRQoL) in a Brazilian population of adults. METHODS: A representative sample from Porto Alegre city was drawn in 2011 using a multistage probability sampling strategy. For this study, 740 individuals, 35-59 years of age and with \>/=6 teeth, were included. GR was assessed by two calibrated examiners at four sites in all present teeth. The Oral Health Impact Profile (OHIP-14) was used to assess OHRQoL. OHIP-14 was dichotomized using {\textquoteright}fairly often{\textquoteright} as the cutoff point for a negative impact. Multiple logistic regression models were fitted to define which descriptors of GR were associated with the dichotomous outcome of OHIP-14, including dentine hypersensitivity in separate models, adjusting for age, gender, socioeconomic status, smoking, dental care, and missing teeth. RESULTS: Mean OHIP was significantly higher for individuals with \>/=1 tooth with GR \>/=2, \>/=3, \>/=4, and \>/=5 mm. Individuals with \>/=1 tooth with GR \>/=2 mm had approximately two times higher chance of having a negative impact than individuals without GR of this threshold [odds ratio (OR) = 1.99, 95\% confidence interval (CI) 1.05-3.78]. When buccal and proximal sites were analyzed separately, the presence of GR was significantly associated with worst quality of life only in anterior and not in posterior teeth. GR in the lower arch had no impact on OHRQoL. GR \>/=2 mm affected only physical pain (OR = 2.61; 95\% CI 1.06-6.42), whereas GR \>/=4 mm affected functional limitation, physical pain, psychological discomfort, physical and psychological disabilities, with ORs ranging from 1.43 to 1.91. Dentine hypersensitivity alone was not associated with OHRQoL, but it modified the association between GR and OHIP when present concomitantly with GR, mainly in buccal sites. CONCLUSIONS: OHRQoL is poorer in this adult population in the presence of GR, mainly in upper and anterior teeth. Dentine hypersensitivity and esthetics were found to be factors linking GR to OHRQoL.

}, keywords = {*Brazil, *epidemiology, *gingival recession, *periodontal diseases, *Quality of Life, *risk assessment, Adult, Brazil/epidemiology, Cross-Sectional Studies, Female, Gingival Recession/*epidemiology, Humans, Male, Middle Aged, Oral Health/*statistics \& numerical data, Socioeconomic Factors}, isbn = {1600-0528 (Electronic)0301-5661 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26957046}, author = {Wagner, T. P. and Costa, R. S. and Rios, F. S. and Moura, M. S. and Maltz, M. and Jardim, J. J. and Haas, A. N.} } @article {6594, title = {Periodontal disease, tooth loss and coronary heart disease assessed by coronary angiography: a cross-sectional observational study}, journal = {J Periodontal Res}, volume = {51}, number = {2}, year = {2016}, note = {

Zanella, S MPereira, S SBarbisan, J NVieira, LSaba-Chujfi, EHaas, A NRosing, C KengJ Periodontal Res. 2016 Apr;51(2):221-7. doi: 10.1111/jre.12301. Epub 2015 Jul 30.

}, month = {Apr}, pages = {221-7}, edition = {2015/08/01}, abstract = {

OBJECTIVE AND BACKGROUND: To evaluate the association between periodontal disease, tooth loss and coronary heart disease (CHD). There is still controversy about the relationship between periodontal disease and tooth loss with vessel obstruction assessed using coronary angiography. MATERIAL AND METHODS: This cross-sectional study included 195 patients that underwent coronary angiography and presented with at least six teeth. Patients were classified into three categories of coronary obstruction severity: absence; one or more vessels with /= 50\% obstruction. The extent of coronary obstruction was dichotomized into 0 and \>/= 1 affected vessels. A periodontist blinded to patient CHD status conducted a full mouth examination to determine mean clinical attachment loss, mean periodontal probing depth and tooth loss. Multiple logistic regression models were applied adjusting for age, gender, hypertension, smoking, body mass index, low-density lipoprotein cholesterol and C-reactive protein. RESULTS: Most patients were males (62.1\%) older than 60 years (50.8\%), and 61\% of them had CHD. Mean periodontal probing depth, clinical attachment loss and tooth loss were 2.64 +/- 0.72 mm, 4.40 +/- 1.31 mm and 12.50 +/- 6.98 teeth respectively. In the multivariable models, tooth loss was significantly associated with a higher chance of having at least one obstructed vessel (odds ratio = 1.04; 95\% confidence interval 1.01-1.09) and with vessel obstruction \>/= 50\% (odds ratio = 1.06; 95\% confidence interval 1.01-1.11). No significant associations were found between periodontal variables and vessel obstruction. CONCLUSION: Tooth loss was found to be a risk indicator for CHD.

}, keywords = {*periodontal diseases, Coronary Angiography, Coronary Disease, Cross-Sectional Studies, Humans, Male, Periodontal Attachment Loss, periodontal disease, Risk Factors, Smoking, Tooth Loss}, isbn = {1600-0765 (Electronic)0022-3484 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26223630}, author = {Zanella, S. M. and Pereira, S. S. and Barbisan, J. N. and Vieira, L. and Saba-Chujfi, E. and Haas, A. N. and Rosing, C. K.} } @article {6590, title = {Self-reported Use of Dental Floss over 13 Years: Relationship with Family Income, Mother{\textquoteright}s Age and Educational Level}, journal = {Oral Health Prev Dent}, volume = {14}, number = {1}, year = {2016}, note = {

Kauer, BrunoSchutz, JasperColussi, Paulo R GOppermann, Rui VHaas, Alex NRosing, Cassiano KengComparative StudyGermanyOral Health Prev Dent. 2016;14(1):33-9. doi: 10.3290/j.ohpd.a34375.

}, pages = {33-9}, edition = {2015/06/25}, abstract = {

PURPOSE: To determine whether family income, age and educational level of the mother of the family are associated with self-reported use of dental floss over a 13-year period in a city in southern Brazil. MATERIALS AND METHODS: A comparison of two household surveys was carried out where mothers of the family were interviewed using a structured questionnaire in order to obtain demographic, behavioural and socioeconomic information. In total, 852 and 984 households were included in 1996 and 2009, respectively. Self-reported use of dental floss was assessed dichotomously (yes/no). Poisson regression models were fitted to study the association between sociodemographic variables with the use of dental floss. Proportion ratios (PR) and 95\% confidence intervals (95\% CI) were reported. RESULTS: The proportion of dental floss use increased from 48\% to 59\% over 13 years. The probability of dental floss use increased 1.23 times from 1996 to 2009 (PR = 1.23; 95\% CI 1.13-1.34). Households with mothers \>/=50 years old presented a 28\% lower probability of using dental floss than households with mothers

}, keywords = {*Educational Status, *Maternal Age, *Self Report, Adult, Brazil, Cross-Sectional Studies, Dental Devices, Home Care/*statistics \& numerical data, Female, Humans, Income/*statistics \& numerical data, Longitudinal Studies, Middle Aged, Poverty/statistics \& numerical data, Social Class, Urban Population}, isbn = {1602-1622 (Print)1602-1622 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26106652}, author = {Kauer, B. and Schutz, J. and Colussi, P. R. and Oppermann, R. V. and Haas, A. N. and Rosing, C. K.} } @article {6585, title = {The association between alcohol consumption and periodontitis in southern Brazilian adults}, journal = {J Periodontal Res}, volume = {50}, number = {5}, year = {2015}, note = {

Susin, CWagner, M CHaas, A NOppermann, R VAlbandar, J MengResearch Support, Non-U.S. Gov{\textquoteright}tJ Periodontal Res. 2015 Oct;50(5):622-8. doi: 10.1111/jre.12242. Epub 2014 Nov 17.

}, month = {Oct}, pages = {622-8}, edition = {2014/11/18}, abstract = {

BACKGROUND AND OBJECTIVE: An association between alcohol consumption and periodontitis has been suggested in the literature, but the evidence is still unclear. The aim of the present study was to investigate the relationship between alcohol consumption and periodontitis in a probability sample of adults from south Brazil. MATERIAL AND METHODS: This analysis included 1115 subjects aged 18-65 years derived from a representative sample from south Brazil. Data were collected from participants from clinical examination and structured interviews. Alcohol consumption was assessed by asking participants about the usual number of drinks consumed in a week. Four categories of alcohol consumption were defined: non-drinker, 1 glass/wk, 1 glass/d. Individuals with \>/= 30\% teeth with periodontal attachment loss \>/= 5 mm were classified as having periodontitis. Logistic models adjusting for age, race, socioeconomic status, dental care, body mass index, self-reported diabetes and smoking were used to estimate odds ratios (OR) and confidence intervals (95\% CI). RESULTS: After adjusting for co-factors, females who reported drinking \> 1 glass/d were more likely to have periodontitis (OR = 3.8, 95\% CI = 1.4-10.1), whereas females who reported drinking up to 1 glass/d were 50\% less likely to have periodontitis (OR = 0.5, 95\% CI = 0.3-0.8). No significant associations between overall alcohol intake and periodontitis were observed for males. In an exploratory analysis, wine consumption was associated with a lower likelihood of periodontitis among males (OR = 0.2, 95\% CI = 0.1-0.5) but not females. CONCLUSION: The periodontal health of males and females appears to be affected differently by alcohol consumption. Moderate wine consumption may have a beneficial effect in males.

}, keywords = {*Periodontitis, Adolescent, Adult, Aged, alcohol consumption, Alcohol Drinking, Brazil, epidemiology, Female, Humans, Male, Middle Aged, Periodontal Attachment Loss, periodontitis, Risk Factors, Smoking, Young Adult}, isbn = {1600-0765 (Electronic)0022-3484 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/25399772}, author = {Susin, C. and Wagner, M. C. and Haas, A. N. and Oppermann, R. V. and Albandar, J. M.} } @article {6580, title = {Randomized controlled clinical trial of the 24-months survival of composite resin restorations after one-step incomplete and complete excavation on primary teeth}, journal = {J Dent}, volume = {43}, number = {10}, year = {2015}, note = {

Franzon, ROpdam, N JGuimaraes, L FDemarco, F FCasagrande, LHaas, A NAraujo, F BengRandomized Controlled TrialEnglandJ Dent. 2015 Oct;43(10):1235-41. doi: 10.1016/j.jdent.2015.07.011. Epub 2015 Jul 29.

}, month = {Oct}, pages = {1235-41}, edition = {2015/08/02}, abstract = {

OBJECTIVE: This randomized clinical trial aimed to compare the 24-months survival of composite restorations in primary molars after partial caries removal (PCR) and total caries removal (TCR). METHODS: Forty-eight children aged 3-8 years with at least one molar with a deep carious lesion were included (PCR; n=66; TCR; n=54). For PCR, excavation was stopped when dentine with a leathery consistency was achieved; in the TCR group, total absence of carious tissue was confirmed using a blunt-tipped probe. Pulpotomy was performed in cases of pulp exposure. Success was assessed by modified USPHS criteria with Alpha and Bravo scores recorded as success. RESULTS: Pulp exposure occurred in 1 and 15 of the teeth treated with PCR and TCR respectively (p\<0.01). The restorations survival rate after 24 months was 66\% (PCR) and 86\% (TCR) (p=0.03). When teeth that received pulpotomy were analyzed separately, the survival rate was 92\% (p=0.09). PCR performed in occlusoproximal restorations demonstrated the lowest success rate (p=0.002). PCR increases 2.90 times the probability of having a restorative failure compared to TCR (p=0.03), after adjusting for cavity type. When pulp exposure and restoration failure were considered as the outcome, there was no significant difference between the two groups (p=0.10) with success rates of 64\% (PCR) and 61\% (TCR). CONCLUSION: Collectively, deciduous teeth submitted to PCR prevented pulp exposure and, consequently, more invasive treatments; otherwise, PCR yielded lower longevity for composite restoration compared to TCR, suggesting that PCR restorations need to be followed over time, especially when multi-surface restorations are involved. CLINICAL SIGNIFICANCE: Composite restorations on carious remaining tissue require monitoring over time, especially those performed in more than one surface. Even if the restorations present shortcomings over the time, the majority of them are subject to repair, allowing more conservative approaches for teeth with deep caries lesions.

}, keywords = {*Clinical trial, *Composite resin, *Dental caries, *Incomplete excavation, *Primary tooth, Child, Child, Preschool, Composite Resins/*therapeutic use, Dental Caries/*therapy, Dental Cavity Preparation, Dental Pulp Exposure/pathology/prevention \& control, Dental Restoration Failure, Dental Restoration, Permanent/*methods, Dentin/pathology, Female, Humans, Male, Molar/pathology, Pulpotomy, Tooth, Deciduous/*pathology, Treatment Outcome}, isbn = {1879-176X (Electronic)0300-5712 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26231301}, author = {Franzon, R. and Opdam, N. J. and Guimaraes, L. F. and Demarco, F. F. and Casagrande, L. and Haas, A. N. and Araujo, F. B.} } @article {6584, title = {Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article}, journal = {World J Cardiol}, volume = {7}, number = {1}, year = {2015}, note = {

Saffi, Marco Aurelio LumertzFurtado, Mariana VargasPolanczyk, Carisi AnneMontenegro, Marlon MunhozRibeiro, Ingrid Webb JosephsonKampits, CassioHaas, Alex NogueiraRosing, Cassiano KuchenbeckerRabelo-Silva, Eneida RejaneengReviewWorld J Cardiol. 2015 Jan 26;7(1):26-30. doi: 10.4330/wjc.v7.i1.26.

}, month = {Jan 26}, pages = {26-30}, edition = {2015/01/30}, abstract = {

Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease.

}, keywords = {Atherosclerosis, Cardiovascular diseases, Endothelium, Vascular, Nitric oxide, Periodontal diseases}, isbn = {1949-8462 (Print)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/25632316}, author = {Saffi, M. A. and Furtado, M. V. and Polanczyk, C. A. and Montenegro, M. M. and Ribeiro, I. W. and Kampits, C. and Haas, A. N. and Rosing, C. K. and Rabelo-Silva, E. R.} } @article {6583, title = {Epidemiology of periodontal diseases in adults from Latin America}, journal = {Periodontol 2000}, volume = {67}, number = {1}, year = {2015}, note = {

Oppermann, Rui VHaas, Alex NRosing, Cassiano KuchenbeckerSusin, CristianoengReviewDenmarkPeriodontol 2000. 2015 Feb;67(1):13-33. doi: 10.1111/prd.12061.

}, month = {Feb}, pages = {13-33}, edition = {2014/12/17}, abstract = {

A decade has passed since we first reviewed the epidemiology of periodontal diseases in Latin America. At that time, lack of population-based studies was the norm and our conclusions were based on very limited evidence. The aim of the present comprehensive review was to update and expand our previous work by providing a broad overview of Latin America and its current social, economic and demographic status and by focusing on the epidemiology of periodontal diseases in Latin American adults published in the last 15 years. The amount of periodontal epidemiological data available has increased but is still restricted to a few countries only. The scope of the literature available has also broadened to include oral health-related quality of life and systemic interactions; however, most studies had methodological limitations that might have biased their results. In general, periodontitis was very prevalent, but severe periodontal destruction was localized. Besides being associated with well-established risk factors, periodontitis was associated with demographics and socio-economic factors in Latin American populations. To advance epidemiological knowledge, population-based cross-sectional and longitudinal studies, using appropriate methodologies, should be the future focus of the research agenda of researchers and public health planners in Latin American countries.

}, keywords = {Adult, Cross-Sectional Studies, Humans, Latin America/epidemiology, Longitudinal Studies, Periodontal Diseases/economics/*epidemiology/*etiology, Prevalence, Public Health, Risk Factors, Socioeconomic Factors}, isbn = {1600-0757 (Electronic)0906-6713 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/25494596}, author = {Oppermann, R. V. and Haas, A. N. and Rosing, C. K. and Susin, C.} } @article {6582, title = {A population-based cohort study of oral health in South Brazil: The Porto Alegre Study}, journal = {Rev Bras Epidemiol}, volume = {18}, number = {2}, year = {2015}, note = {

Haas, Alex NogueiraGaio, Eduardo JoseWagner, Marcius ComparsiRios, Fernando SilvaCosta, Ricardo dos Santos AraujoRosing, Cassiano KuchenbeckerOppermann, Rui VicenteAlbandar, JasimSusin, CristianoengporResearch Support, Non-U.S. Gov{\textquoteright}tBrazilRev Bras Epidemiol. 2015 Apr-Jun;18(2):515-9. doi: 10.1590/1980-5497201500020018.

}, month = {Apr-Jun}, pages = {515-9}, edition = {2015/06/18}, abstract = {

Few population-based cohort studies have been established in Dentistry and this is especially true for Latin America. We conducted a population-based prospective study focusing on oral health in Porto Alegre, south Brazil, and herein we describe its methodology and discuss directions for further research. The cohort was established in 2001 using a multistage probability sample of 1,465 toothed and 121 edentulous subjects. A 5-year follow-up was performed in 2006 that included 755 individuals. The main aim of this study was to determine the pattern and risk factors for periodontal disease progression and tooth loss incidence. A full-mouth protocol was used including periodontal assessments at six sites per tooth. Primary outcomes were periodontal attachment loss and tooth loss. Oral mucosal lesions, dental plaque, gingivitis, supragingival calculus, probing depths, gingival recession, and dental caries were also assessed. This is the first population-based cohort study to focus on periodontal disease in Latin America. Findings will contribute to our understanding of the epidemiology of periodontal disease and provide valuable data for the planning and implementation of preventive and therapeutic strategies.

}, keywords = {*Oral Health, Brazil/epidemiology, Cohort Studies, Follow-Up Studies, Humans, Middle Aged, Risk Factors}, isbn = {1980-5497 (Electronic)1415-790X (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26083520}, author = {Haas, A. N. and Gaio, E. J. and Wagner, M. C. and Rios, F. S. and Costa Rdos, S. and Rosing, C. K. and Oppermann, R. V. and Albandar, J. and Susin, C.} } @article {6581, title = {Influence of supragingival biofilm control and smoking habit on Interleukin-1beta concentration}, journal = {Braz Oral Res}, volume = {29}, number = {1}, year = {2015}, note = {

Gomes, Sabrina CarvalhoAbascal, Carolina CoradiniHaas, Alex NogueiraAngst, Patricia Daniela MelchiorsOppermann, Rui VicenteMarcantonio, Rosemary Adriana ChiericiengComparative StudyBrazilBraz Oral Res. 2015;29(1):S1806-83242015000100302. doi: 10.1590/1807-3107BOR-2015.vol29.0115. Epub 2015 Oct 9.

}, pages = {S1806-83242015000100302}, edition = {2016/02/20}, abstract = {

This investigation compared gingival crevicular fluid (GCF) interleukin-1beta (IL-1beta) concentrations in periodontitis patients subjected to a strict supragingival biofilm control (Supra) for 6 months. Never-smokers (23) and smokers (n = 20; 19.6 +/- 11.8 cigarettes/day) moderate-to-severe chronic periodontitis patients underwent a 6 months period of supragingival control with weekly recall visits. Periodontal probing depth (PPD), bleeding on probing (BOP) and GCF samples (from different PPD category sites: 3-5 mm and 6-10 mm) were obtained at the baseline, 30, and 180 days. IL-1beta was assessed by enzyme-linked immunosorbent assay. Generalized estimating equations were used to fit prediction models of IL-1beta changes, considering the dependence between the examinations, and using only data from experimental sites. Overall IL-1beta concentrations decreased from 3.2 pg/microL to 1.9 pg/microL. Higher baseline IL-1beta concentrations were associated with higher baseline PPD values in both groups. There were no differences in IL-1beta concentrations between never-smokers and smokers over time for any PPD category. Higher baseline PPD values and the presence of BOP on day 180 were significantly associated with higher IL-1beta concentrations. A strict Supra regimen reduced IL-1beta concentrations over time in periodontitis patients. The benefits observed for smokers underline the importance of oral hygiene measures, even considering the presence of this important risk factor.

}, keywords = {*Biofilms, Adult, Dental Plaque/prevention \& control, Enzyme-Linked Immunosorbent Assay, Female, Gingival Crevicular Fluid/*chemistry, Humans, Interleukin-1beta/*analysis, Male, Middle Aged, Multivariate Analysis, Periodontal Index, Periodontitis/*microbiology/*therapy, Reference Values, Risk Factors, Smoking/*adverse effects, Time Factors}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {https://www.ncbi.nlm.nih.gov/pubmed/26892351}, author = {Gomes, S. C. and Abascal, C. C. and Haas, A. N. and Angst, P. D. and Oppermann, R. V. and Marcantonio, R. A.} } @article {703, title = {Factors associated with self-reported use of mouthwashes in southern Brazil in 1996 and 2009}, journal = {Int J Dent Hyg}, volume = {12}, number = {2}, year = {2014}, note = {

Montenegro, M MFlores, M FColussi, P R GOppermann, R VHaas, A NRosing, C KengEngland2013/09/17 06:00Int J Dent Hyg. 2014 May;12(2):103-7. doi: 10.1111/idh.12052. Epub 2013 Sep 3.

}, month = {May}, pages = {103-7}, abstract = {

OBJECTIVE: To evaluate the association between sociodemographic factors and self-reported use of mouthwashes in a city in the south of Brazil over a time span of 13 years. METHODS: The study involves a comparison of two household surveys conducted in 1996 and 2009. Respectively, 850 and 982 households were included in each year. The mother of the family answered to a structured questionnaire to provide sociodemographic data. Self-reported use of mouthwash was evaluated in a binary manner (yes/no). Multivariate Poisson regression models were used to estimate proportion ratios (PR) and 95\% confidence intervals (95\% CI). RESULTS: The proportion of mouthwash use increased significantly from 10.8\% to 24.2\% after 13 years. The probability of using mouthwashes increased more than two times from 1996 to 2009 (PR = 2.25 95\% CI 1.80-2.82). Higher probabilities for using mouthwashes were observed in households with higher income (PR = 2.63 95\% CI 1.97-3.51) and in those households where the mothers had higher educational levels (PR = 1.46 95\% CI 1.05-2.03). CONCLUSION: Higher family income and higher maternal educational level were associated with self-reported use of mouthwashes in a higher proportion of households.

}, isbn = {1601-5037 (Electronic)1601-5029 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24034821}, author = {Montenegro, M. M. and Flores, M. F. and Colussi, P. R. and Oppermann, R. V. and Haas, A. N. and Rosing, C. K.} } @article {704, title = {Risk factors for the progression of periodontal attachment loss: a 5-year population-based study in South Brazil}, journal = {J Clin Periodontol}, volume = {41}, number = {3}, year = {2014}, note = {

Haas, Alex NogueiraWagner, Marcius ComparsiOppermann, Rui VicenteRosing, Cassiano KuchenbeckerAlbandar, Jasim MSusin, CristianoengResearch Support, Non-U.S. Gov{\textquoteright}t2013/12/07 06:00J Clin Periodontol. 2014 Mar;41(3):215-23. doi: 10.1111/jcpe.12213. Epub 2014 Jan 12.

}, month = {Mar}, pages = {215-23}, abstract = {

AIM: To assess sociodemographic and behavioural risk factors for periodontal attachment loss (PAL) progression after 5 years in an urban sample from south Brazil. METHODS: At baseline, 1586 subjects, 14 years and older, were derived using a multistage probabilistic sample strategy. At follow-up, 653 of 755 subjects had \>/=6 teeth and were included in this analysis. A modified multiple Poisson regression was used to calculate adjusted relative risks (RR) and 95\% confidence intervals (CI). RESULTS: Overall, 247 (37.8\%) subjects exhibited PAL progression \>/=3 mm in \>/=4 teeth. Subjects older than 30 years had approximately two times higher risk of having PAL progression than younger subjects. Subjects with low education had 53\% higher risk (RR = 1.53; 95\% CI:1.06-2.22) of PAL progression compared to those with high education. A significant interaction between gender and smoking was observed. Among never-smokers, males were 33\% more likely (RR = 1.33; 95\% CI:1.06-1.66) to experience PAL progression than females. Among smokers, there was 8\% increased risk of PAL progression (RR = 1.08; 95\% CI:1.01-1.14) for males and 21\% (RR = 1.21; 95\% CI:1.11-1.33) for females per 10 packyears. Skin colour, socioeconomy, dental care and diabetes were not significantly associated with PAL progression after statistical adjustment. CONCLUSION: Sociodemographic factors and smoking are independent risk factors for PAL progression in this Brazilian population.

}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24304168}, author = {Haas, A. N. and Wagner, M. C. and Oppermann, R. V. and Rosing, C. K. and Albandar, J. M. and Susin, C.} } @article {702, title = {Epidemiology and demographics of aggressive periodontitis}, journal = {Periodontol 2000}, volume = {65}, number = {1}, year = {2014}, note = {

Susin, CristianoHaas, Alex NAlbandar, Jasim MengDenmark2014/04/18 06:00Periodontol 2000. 2014 Jun;65(1):27-45. doi: 10.1111/prd.12019.

}, month = {Jun}, pages = {27-45}, abstract = {

Epidemiologic studies of aggressive periodontitis have used different study designs and a range of examination methods and case definitions, and this greatly complicates the study of disease prevalence in populations. The wide range of disease case definitions, in particular, profoundly impacts the reported rate of disease, and the use of a standard disease definition is strongly recommended. Surveys of aggressive periodontitis that use only clinical examinations, without radiographic examination to confirm the presence of a distinctive pattern of tissue loss, may overestimate the prevalence of this disease, particularly when a low threshold of attachment loss is used. The prevalence of aggressive periodontitis varies significantly between populations, and differences in race/ethnicities seem to be a key factor. Studies consistently show that aggressive periodontitis is most prevalent in Africa and in populations of African descent and is least prevalent in Caucasians in Europe and North America. Among children and young adults the prevalence of this disease is higher in older than in younger age groups. Most studies show comparable disease prevalence in male and female subjects. These findings show that aggressive periodontitis is a significant health problem in certain populations. This review also highlights a lack of information on the epidemiology and demographics of this disease in many parts of the world, particularly in Asia and Africa. Epidemiologic studies of aggressive periodontitis in high-risk populations are important and could provide vital data on the determinants of this disease, and this information is needed for the establishment of effective health-promotion measures.

}, isbn = {1600-0757 (Electronic)0906-6713 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24738585}, author = {Susin, C. and Haas, A. N. and Albandar, J. M.} } @article {707, title = {Prevalence and Risk Indicators of Dentin Hypersensitivity in Adult and Elderly Populations From Porto Alegre, Brazil}, journal = {J Periodontol}, year = {2014}, note = {

Costa, Ricardo S ARios, Fernando SMoura, Mauricio SJardim, Juliana JMaltz, MarisaHaas, Alex NENG2014/02/18 06:00J Periodontol. 2014 Feb 14.

}, month = {Feb 14}, abstract = {

Background: Dentin hypersensitivity (DH) is a clinical condition with potential implications for patients. However, little is known about its occurrence and determinants in the general population. The aim of this study was to assess the prevalence and risk indicators of DH in Porto Alegre, Brazil. Methods: A representative multistage probability sample of 1,023 adults aged \>/=35 years was obtained. Individuals were interviewed and were clinically examined in their homes. DH was assessed dichotomously in all present teeth by a blast of air and a manual probe. Teeth restored with crowns and presenting with carious cavitation were excluded. Survey logistic regression using sampling weights was applied to assess demographics, behavioral and clinical determinants. Results: Overall prevalence estimates for DH diagnosed by air and probe were 33.4\% and 34.2\%. DH affected 1.0 tooth per individual, and approximately 10\% of teeth with gingival recession (GR) had DH. In a multivariate model for DH diagnosed with air, females had increased chance of DH [odds ratio (OR): 2.14; 95\% confidence interval (CI): 1.57-2.91]. Smoking, periodontal treatment, and GR were also associated with increased DH chances. The chance of DH was lower (OR: 0.47, 95\% CI: 0.29-0.76) among individuals \>/=60 than 35 to 49 years old. Oral hygiene practices, socioeconomic and educational statuses, dental visits, and gingival inflammation were not associated with DH. Conclusion: DH may be considered a concern in a Brazilian general population. Reduction of DH may be achieved by smoking cessation and periodontal health improvements.

}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24527854}, author = {Costa, R. S. and Rios, F. S. and Moura, M. S. and Jardim, J. J. and Maltz, M. and Haas, A. N.} } @article {705, title = {Outcomes of One-Step Incomplete and Complete Excavation in Primary Teeth: A 24-Month Randomized Controlled Trial}, journal = {Caries Res}, volume = {48}, number = {5}, year = {2014}, note = {

Franzon, RenataGuimaraes, Lizandra FMagalhaes, Camila EHaas, Alex NAraujo, Fernando BENG2014/04/16 06:00Caries Res. 2014 Apr 8;48(5):376-383.

}, month = {Apr 8}, pages = {376-383}, abstract = {

Aim: To compare 24-month pulp health outcomes of partial caries removal (PCR) and total caries removal (TCR) with composite restoration in primary molars. Methods: 48 children aged 3-8 years with at least one molar with a deep carious lesion were included. 120 teeth were randomized to control (TCR; n = 54; 69\% class II) and test (PCR; n = 66; 63\% class II) groups. Total absence of carious tissue was confirmed using a blunt-tipped probe in the TCR group. For PCR, excavation was stopped when hardened, dried dentin with a leathery consistency was achieved. Pulpotomy was performed in cases of pulp exposure. Results: Pulp exposure occurred in 2 and 27.5\% of teeth treated with PCR and TCR, respectively (p \< 0.01). The operative time was significantly higher for TCR than PCR. Success rates were 92 and 96\% in the PCR and TCR groups, respectively (p = 0.34). The success rate tended to be lower in occlusoproximal (92\%) than in occlusal (100\%) lesions (p = 0.08). Conclusion: The clinical and radiographic success rates of PCR and TCR in primary teeth with deep carious lesions were high and did not differ significantly, indicating that PCR is a reliable minimally invasive approach in primary teeth and that the retention of carious dentin does not interfere with pulp vitality. Moreover, PCR provided other clinically relevant advantages over TCR, especially lower incidence of pulp exposure and lower operative time. (c) 2014 S. Karger AG, Basel.

}, isbn = {1421-976X (Electronic)0008-6568 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24732081}, author = {Franzon, R. and Guimaraes, L. F. and Magalhaes, C. E. and Haas, A. N. and Araujo, F. B.} } @article {706, title = {Periodontal status affects C-reactive protein and lipids in patients with stable heart disease from a tertiary care cardiovascular clinic}, journal = {J Periodontol}, volume = {85}, number = {4}, year = {2014}, note = {

Flores, Manuela FMontenegro, Marlon MFurtado, Mariana VPolanczyk, Carisi ARosing, Cassiano KHaas, Alex Neng2013/06/29 06:00J Periodontol. 2014 Apr;85(4):545-53. doi: 10.1902/jop.2013.130255. Epub 2013 Jun 27.

}, month = {Apr}, pages = {545-53}, abstract = {

BACKGROUND: There are scarce data on the impact of the periodontal condition in the control of biomarkers in patients with cardiovascular disease (CVD). The aim of this study is to assess whether periodontal inflammation and tissue breakdown are associated with C-reactive protein (CRP) and lipids in patients with stable heart disease. METHODS: This cross-sectional study included 93 patients with stable coronary artery disease (57 males; mean age: 63.5 +/- 9.8 years) who were in outpatient care for at least 6 months. After applying a structured questionnaire, periodontal examinations were performed by two calibrated periodontists in six sites per tooth at all teeth. Blood samples were collected from patients on the day of periodontal examination to determine levels of CRP, lipids, and glycated hemoglobin. Multiple linear regression models were fitted to evaluate the association among different periodontal and blood parameters controlling for sex, body mass index, glycated hemoglobin, use of oral hypoglycemic drugs, and smoking. RESULTS: Overall, the sample presented high levels of periodontal inflammation and tissue breakdown. Unadjusted mean concentrations of triglycerides (TGs), very-low-density lipoprotein cholesterol, and glucose were significantly higher in individuals with severe periodontitis. When multiple linear regression models were applied, number of teeth with clinical attachment loss \>/=6 mm and presence of severe periodontitis were significantly associated with higher CRP concentrations. Bleeding on probing was significantly associated with TGs, total cholesterol, and non-high-density lipoprotein cholesterol. CONCLUSION: In this sample of patients with stable CVD, current periodontal inflammation and tissue breakdown are associated with cardiovascular inflammatory markers, such as CRP and lipid profile.

}, isbn = {1943-3670 (Electronic)0022-3492 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23805809}, author = {Flores, M. F. and Montenegro, M. M. and Furtado, M. V. and Polanczyk, C. A. and Rosing, C. K. and Haas, A. N.} } @article {710, title = {Incomplete caries removal and indirect pulp capping in primary molars: a randomized controlled trial}, journal = {Am J Dent}, volume = {26}, number = {4}, year = {2013}, note = {

Bressani, Ana Eliza LemesMariath, Adriela Azevedo SouzaHaas, Alex NogueiraGarcia-Godoy, Franklinde Araujo, Fernando BorbaengComparative StudyRandomized Controlled Trial2014/04/04 06:00Am J Dent. 2013 Aug;26(4):196-200.

}, month = {Aug}, pages = {196-200}, abstract = {

PURPOSE: To compare the effect of incomplete caries removal (ICR) and indirect pulp capping (IPC) with calcium hydroxide (CH) or an inert material (wax) on color, consistency and contamination of the remaining dentin of primary molars. METHODS: This double-blind, parallel-design, randomized controlled trial included 30 children presenting one primary molar with deep caries lesion. Children were randomly assigned after ICR to receive IPC with CH or wax. All teeth were then restored with resin composite. Baseline dentin color and consistency were evaluated after ICR, and dentin samples were collected for contamination analyses using scanning electron microscopy. After 3 months, restorations were removed and the three parameters were re-evaluated. In both groups, dentin became significantly darker after 3 months. RESULTS: No cases of yellow dentin were observed after 3 months with CH compared to 33.3\% of the wax cases (P \< 0.05). A statistically significant difference over time was observed only for CH regarding consistency. CH stimulated a dentin hardening process in a statistically higher number of cases than wax (86.7\% vs. 33.3\%; P = 0.008). Contamination changed significantly over time in CH and wax without significant difference between groups. It was concluded that CH and wax arrested the carious process of the remaining carious dentin after indirect pulp capping, but CH showed superior dentin color and consistency after 3 months.

}, keywords = {Calcium Hydroxide/therapeutic use, Child, Child, Preschool, Color, Composite Resins/chemistry, Dental Caries/microbiology/pathology/*therapy, Dental Cavity Preparation/instrumentation/*methods, Dental Materials/chemistry, Dental Pulp Capping/*methods, Dental Restoration, Permanent/methods, Dentin, Secondary/drug effects/pathology, Dentin/pathology, Double-Blind Method, Female, Follow-Up Studies, Humans, Male, Microscopy, Electron, Scanning, Molar/microbiology/*pathology, Pulp Capping and Pulpectomy Agents/therapeutic use, Resin Cements/chemistry, Tooth, Deciduous/microbiology/*pathology, Waxes/therapeutic use}, isbn = {0894-8275 (Print)0894-8275 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24693629}, author = {Bressani, A. E. and Mariath, A. A. and Haas, A. N. and Garcia-Godoy, F. and de Araujo, F. B.} } @article {709, title = {The incidence of gingival fissures associated with toothbrushing: crossover 28-day randomized trial}, journal = {J Clin Periodontol}, volume = {40}, number = {4}, year = {2013}, note = {

Greggianin, Bruna FrizonOliveira, Sara CioccariHaas, Alex NogueiraOppermann, Rui VicenteengRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}t2013/02/22 06:00J Clin Periodontol. 2013 Apr;40(4):319-26. doi: 10.1111/jcpe.12072. Epub 2013 Feb 21.

}, month = {Apr}, pages = {319-26}, abstract = {

AIM: To compare the incidence of gingival fissures after the use of soft and medium-hard toothbrushes. MATERIAL \& METHODS: Overall, 35 participants (14-20 years old), with periodontal attachment loss (PAL)

}, keywords = {Adolescent, Cross-Over Studies, Dental Plaque/complications, Female, Gingival Diseases/*etiology, Humans, Linear Models, Male, Multivariate Analysis, Periodontal Attachment Loss/complications, Sex Factors, Single-Blind Method, Time Factors, Toothbrushing/*adverse effects, Young Adult}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23425194}, author = {Greggianin, B. F. and Oliveira, S. C. and Haas, A. N. and Oppermann, R. V.} } @article {708, title = {The effect of periodontal therapy on C-reactive protein, endothelial function, lipids and proinflammatory biomarkers in patients with stable coronary artery disease: study protocol for a randomized controlled trial}, journal = {Trials}, volume = {14}, year = {2013}, note = {

Saffi, Marco Aurelio LumertzFurtado, Mariana VargasMontenegro, Marlon MunhozRibeiro, Ingrid Webb JosephsonKampits, CassioRabelo-Silva, Eneida RejanePolanczyk, Carisi AnneRosing, Cassiano KuchenbeckerHaas, Alex NogueiraengResearch Support, Non-U.S. Gov{\textquoteright}tEngland2013/09/10 06:00Trials. 2013 Sep 6;14:283. doi: 10.1186/1745-6215-14-283.

}, pages = {283}, abstract = {

BACKGROUND: Scarce information exists regarding the preventive effect of periodontal treatment in the recurrence of cardiovascular events. Prevention may be achieved by targeting risk factors for recurrent coronary artery disease (CAD) in patients with previous history of cardiovascular events. The aim of this trial is to compare the effect of two periodontal treatment approaches on levels of C-reactive protein, lipids, flow-mediated dilation and serum concentrations of proinflammatory and endothelial markers in stable CAD patients with periodontitis over a period of 12 months. METHODS/DESIGN: This is a randomized, parallel design, examiner blinded, controlled clinical trial. Individuals from both genders, 35 years of age and older, with concomitant diagnosis of CAD and periodontitis will be included. CAD will be defined as the occurrence of at least one of the following events 6 months prior to entering the trial: documented history of myocardial infarction; surgical or percutaneous myocardial revascularization and lesion \>50\% in at least one coronary artery assessed by angiography; presence of angina and positive noninvasive testing of ischemia. Diagnosis of periodontitis will be defined using the CDC-AAP case definition (\>/=2 interproximal sites with clinical attachment loss \>/=6 mm and \>/=1 interproximal site with probing depth \>/=5 mm). Individuals will have to present at least ten teeth present to be included. One hundred individuals will be allocated to test (intensive periodontal treatment comprised by scaling and root planing) or control (community periodontal treatment consisting of one session of supragingival plaque removal only) treatment groups. Full-mouth six sites per tooth periodontal examinations and subgingival biofilm samples will be conducted at baseline, 3, 6 and 12 months after treatment. The primary outcome of this study will be C-reactive protein changes over time. Secondary outcomes include levels of total cholesterol, LDL-C, HDL-C, triglycerides, IL-1beta, IL-6, TNFalpha, fibrinogen, ICAM-1, VCAM-1 and E-selectin. These outcomes will be assessed at all time points over 12 months. Flow-mediated dilation will be assessed at baseline, 1, 3 and 6 months after periodontal therapy. DISCUSSION: This trial will provide new evidence regarding the effect of periodontal treatment on risk markers for recurrence of cardiovascular events in stable coronary artery disease patients. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Identifier, NCT01609725.

}, isbn = {1745-6215 (Electronic)1745-6215 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24010954}, author = {Saffi, M. A. and Furtado, M. V. and Montenegro, M. M. and Ribeiro, I. W. and Kampits, C. and Rabelo-Silva, E. R. and Polanczyk, C. A. and Rosing, C. K. and Haas, A. N.} } @article {715, title = {Oral health status in elders from South Brazil: a population-based study}, journal = {Gerodontology}, volume = {29}, number = {3}, year = {2012}, note = {

Gaio, Eduardo JHaas, Alex NCarrard, Vinicius COppermann, Rui VAlbandar, JasimSusin, CristianoengResearch Support, Non-U.S. Gov{\textquoteright}tEngland2012/04/11 06:00Gerodontology. 2012 Sep;29(3):214-23. doi: 10.1111/j.1741-2358.2011.00617.x. Epub 2012 Apr 9.

}, month = {Sep}, pages = {214-23}, abstract = {

OBJECTIVE: To assess the oral health status of community-dwelling adults aged 60 years and older from southern Brazil and to determine demographics, socioeconomic, behavioural and dental risk indicators. MATERIALS AND METHODS: This cross-sectional study used a multistage, probability sampling method to draw a representative sample of the metropolitan area of Porto Alegre, Brazil. A subsample of 217 subjects was included in this analysis. Oral mucosal lesions, dental caries, tooth loss and periodontal status (full-mouth, six sites per tooth exam) were assessed by calibrated examiners. RESULTS: Prevalence of edentulism was 39.5\%, and mean tooth loss was 20.2 (SE = 0.6). Older individuals [Odds Ratio (OR) = 2.2], women (OR = 2.3), white people (OR = 5.9), individuals of lower socioeconomic status (OR = 5.6) and smokers (OR = 3.5) had higher likelihood of being edentulous. Approximately 36\% of dentate individuals had caries and/or restoration affecting, in average, 5.0 teeth. Periodontitis affected 79\% of subjects, and it was associated with older age (OR = 4.0), men (OR = 3.4) and large amounts of supragingival plaque (OR = 3.0). CONCLUSION: Poor oral health was observed in this elderly population from South Brazil. Sociodemographic disparities accounted for most of the burden of disease and treatment needs.

}, keywords = {Age Factors, Aged, Aged, 80 and over, Brazil/epidemiology, Cross-Sectional Studies, Dental Caries/*epidemiology, Female, Humans, Logistic Models, Male, Middle Aged, Mouth, Edentulous/*epidemiology, Oral Health/*statistics \& numerical data, Periodontitis/*epidemiology, Prevalence, Risk Factors, Sex Factors, Socioeconomic Factors, Tooth Loss/*epidemiology}, isbn = {1741-2358 (Electronic)0734-0664 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22486627}, author = {Gaio, E. J. and Haas, A. N. and Carrard, V. C. and Oppermann, R. V. and Albandar, J. and Susin, C.} } @article {711, title = {A 10-year study of specimens submitted to oral pathology laboratory analysis: lesion occurrence and demographic features}, journal = {Braz Oral Res}, volume = {26}, number = {3}, year = {2012}, note = {

Mendez, MarinaCarrard, Vinicius CoelhoHaas, Alex NogueiraLauxen, Isabel da SilvaBarbachan, Joao Jorge DinizRados, Pantelis VarvakiSant{\textquoteright}Ana Filho, ManoelengResearch Support, Non-U.S. Gov{\textquoteright}tBrazil2012/05/30 06:00Braz Oral Res. 2012 May-Jun;26(3):235-41.

}, month = {May-Jun}, pages = {235-41}, abstract = {

The purpose of the present paper was to describe the range of lesions histologically diagnosed in an oral pathology laboratory in southern Brazil. A retrospective study of 8,168 specimen analyses recorded between 1995 and 2004 was conducted. The records were retrieved from the Oral Pathology Laboratory, School of Dentistry, Federal University of Rio Grande do Sul, RS, Brazil. A total of 6,831 valid cases (83.63\%) were examined. Of these, inflammatory lesions were the most common occurrences (n = 4,320; 63.24\%). Benign and malignant tumors accounted for 7.66\% (n = 523) and 1.9\% (n = 130) of the occurrences, respectively. Significant associations were observed between nonneoplastic proliferative disorders and benign mesenchymal tumors in females, and between squamous cell carcinoma and leukoplakia in males. Most diagnoses were benign in nature and had an inflammatory etiology. The association of some demographic characteristics with the occurrence of lesions suggests that these characteristics should be considered in performing differential diagnoses.

}, keywords = {Adult, Age Distribution, Brazil/epidemiology, Carcinoma, Squamous Cell/epidemiology/pathology, Female, Humans, Logistic Models, Male, Middle Aged, Mouth Diseases/*epidemiology/pathology, Mouth Neoplasms/epidemiology/pathology, Odds Ratio, Pathology, Oral/*statistics \& numerical data, Retrospective Studies, Sex Distribution}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22641443}, author = {Mendez, M. and Carrard, V. C. and Haas, A. N. and Lauxen Ida, S. and Barbachan, J. J. and Rados, P. V. and Sant{\textquoteright}Ana Filho, M.} } @article {712, title = {Adjunctive azithromycin in the treatment of aggressive periodontitis: microbiological findings of a 12-month randomized clinical trial}, journal = {J Dent}, volume = {40}, number = {7}, year = {2012}, note = {

Haas, Alex NogueiraSilva-Boghossian, Carina MacielColombo, Ana PaulaSusin, CristianoAlbandar, Jasim MOppermann, Rui VicenteRosing, Cassiano KuchenbeckerengComparative StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}tEngland2012/03/27 06:00J Dent. 2012 Jul;40(7):556-63. doi: 10.1016/j.jdent.2012.03.004. Epub 2012 Mar 20.

}, month = {Jul}, pages = {556-63}, abstract = {

OBJECTIVES: To compare the subgingival microbiological outcomes of azithromycin or placebo as adjuncts to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP), and to secondarily evaluate the microbiological effect of supragingival scaling in AgP patients. METHODS: Twenty-four AgP subjects 13-26 years of age received a 15-day programme of supragingival scaling (SC) and were then randomly assigned to SRP with systemic azithromycin or placebo. Subgingival samples were taken with sterile paper points at baseline, 15 days after SC, and at 3, 6 and 12 months following SRP. Microbiological analysis was performed by the checkerboard DNA-DNA hybridization. RESULTS: Changes in bacterial levels from baseline to 15 days after SC were similar in the 2 groups. When subjects were analysed as a single group, significant reductions after SC were observed for Actinomyces gerencseriae, Capnocytophaga ochracea, and Treponema denticola. During the 12-month follow-up, levels of most of the bacteria decreased in both groups in a similar pattern. For instance, Actinomyces israelli, Veillonella parvula, Streptococcus gordonii, C. ochracea, Eikenella corrodens, Eubacterium nodatum, Fusobacterium periodonticum and Fusobacterium nucleatum ssp. polymorphum decreased significantly within the groups. CONCLUSIONS: Azithromycin was ineffective in lowering the subgingival levels of important putative periodontal pathogens in young AgP subjects compared to placebo. CLINICAL SIGNIFICANCE: Scaling and root planing with adjunctive systemic azithromycin provides little additional benefit compared to placebo in reductions of major subgingival periodontal pathogens.

}, keywords = {*Root Planing, Actinomyces/drug effects, Adolescent, Adult, Aggressive Periodontitis/microbiology/*therapy, Anti-Bacterial Agents/*therapeutic use, Azithromycin/*therapeutic use, Bacteria/classification/drug effects, Capnocytophaga/drug effects, Dental Plaque/microbiology, Dental Scaling/*methods, Double-Blind Method, Eikenella corrodens/drug effects, Eubacterium/drug effects, Follow-Up Studies, Fusobacterium nucleatum/drug effects, Fusobacterium/drug effects, Humans, Placebos, Prevotella intermedia/drug effects, Streptococcus gordonii/drug effects, Treatment Outcome, Treponema denticola/drug effects, Veillonella/drug effects, Young Adult}, isbn = {1879-176X (Electronic)0300-5712 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22445846}, author = {Haas, A. N. and Silva-Boghossian, C. M. and Colombo, A. P. and Susin, C. and Albandar, J. M. and Oppermann, R. V. and Rosing, C. K.} } @article {714, title = {Pattern and rate of progression of periodontal attachment loss in an urban population of South Brazil: a 5-years population-based prospective study}, journal = {J Clin Periodontol}, volume = {39}, number = {1}, year = {2012}, note = {

Haas, Alex NogueiraGaio, Eduardo JoseOppermann, Rui VicenteRosing, Cassiano KuchenbeckerAlbandar, Jasim MSusin, CristianoengDenmark2011/11/19 06:00J Clin Periodontol. 2012 Jan;39(1):1-9. doi: 10.1111/j.1600-051X.2011.01818.x. Epub 2011 Nov 14.

}, month = {Jan}, pages = {1-9}, abstract = {

AIM: The aim of this 5-years longitudinal study was to investigate the pattern and rate of periodontal attachment loss (PAL) progression in an urban population in South Brazil. METHODS: In 2001, a multistage probability sampling strategy was used to derive a representative sample of 1,465 dentate individuals from Porto Alegre, Brazil. Five years later, 697 dentate individuals (294M/403F, mean age: 37.9 +/- 13.3) were available for follow-up. PAL was assessed by calibrated examiners using a full-mouth protocol. Estimates of proximal PAL progression and standard errors (SE) are reported. RESULTS: Fifty-six per cent (SE: 1.9) and 36\% (SE: 1.8) of subjects showed PAL progression \>/=3 mm affecting \>/=2 and \>/=4 teeth respectively. PAL progression \>/=3 mm was mostly localized affecting 3.8 (SE: 0.2) teeth and 5.7 (SE: 0.3) sites. Annual PAL progression was, on average, 0.3 mm (SE: 0.01). Significant differences in PAL progression were observed according to age, gender, race and socioeconomic status. PAL progression increased with age reaching the highest progression rate in the 40-49 years cohort, and then decreased in older age groups. PAL progression was consistently higher among males and non-Whites than females and whites. CONCLUSION: A large proportion of this urban Brazilian sample was affected by PAL progression underscoring the need for health promotion initiatives aiming at preventing progression of destructive periodontal disease.

}, keywords = {*Dental Health Surveys, *Population Surveillance, Adolescent, Adult, Aged, Aged, 80 and over, Brazil/epidemiology, Disease Progression, Female, Humans, Longitudinal Studies, Male, Middle Aged, Periodontal Attachment Loss/*epidemiology, Prospective Studies, Urban Population, Young Adult}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22093104}, author = {Haas, A. N. and Gaio, E. J. and Oppermann, R. V. and Rosing, C. K. and Albandar, J. M. and Susin, C.} } @article {713, title = {Azithromycin as an adjunctive treatment of aggressive periodontitis: radiographic findings of a 12-month randomized clinical trial}, journal = {Am J Dent}, volume = {25}, number = {4}, year = {2012}, note = {

Haas, Alex NogueiraSeleme, FrancineSegatto, PaulaSusin, CristianoAlbandar, JasimOppermann, Rui VicenteFontanella, Vania ReginaRosing, Cassiano KuchenbeckerengComparative StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}t2012/10/23 06:00Am J Dent. 2012 Aug;25(4):215-9.

}, month = {Aug}, pages = {215-9}, abstract = {

PURPOSE: To compare the 12-month radiographic outcomes following the use of azithromycin or placebo as adjuncts to non-surgical periodontal treatment of AgP. METHODS: 17 aggressive periodontitis (AgP) subjects 13-26 years old were randomly assigned to receive scaling and root planing (SRP) with systemic azithromycin or placebo. Standardized radiographs were taken at baseline and 12 months postoperatively. Recall visits consisting of oral prophylaxis and oral hygiene instructions were performed during the 12 months. Digital image subtraction analysis and linear bone measurements were conducted by a blinded and calibrated examiner. Student t-tests were used for within and between-groups comparisons. ANCOVA was applied for between-group comparisons of changes in linear bone level adjusting for baseline values. RESULTS: There were significant gains in linear bone levels in the azithromycin (0.55 +/- 0.10 mm) and placebo (0.42 +/- 0.07 mm) groups between the baseline and 12-month postoperative visits. There were also significant gains in bone density in the two treatment groups. No significant differences were observed between the two treatments in the amount of linear bone gain or bone density during the follow-up period. The use of azithromycin as an adjunct to SRP in the treatment of AgP did not result in significant radiographic bone level changes compared to placebo.

}, keywords = {*Dental Scaling, Adolescent, Adult, Aggressive Periodontitis/*drug therapy/radiography/therapy, Alveolar Bone Loss/drug therapy/*radiography/therapy, Analysis of Variance, Anti-Bacterial Agents/*therapeutic use, Azithromycin/*therapeutic use, Bone Density, Chemotherapy, Adjuvant, Female, Humans, Image Processing, Computer-Assisted, Male, Single-Blind Method, Subtraction Technique, Young Adult}, isbn = {0894-8275 (Print)0894-8275 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23082385}, author = {Haas, A. N. and Seleme, F. and Segatto, P. and Susin, C. and Albandar, J. and Oppermann, R. V. and Fontanella, V. R. and Rosing, C. K.} } @article {716, title = {Factors associated with changes in self-reported dentifrice consumption in a Brazilian group from 1996 and 2009}, journal = {Braz Dent J}, volume = {23}, number = {6}, year = {2012}, note = {

Colussi, Paulo Roberto GrafittiHaas, Alex NogueiraOppermann, Rui VicenteRosing, Cassiano KuchenbeckerengBrazil2013/01/23 06:00Braz Dent J. 2012;23(6):737-45.

}, pages = {737-45}, abstract = {

The aim of the study was to determine factors associated with changes in self-reported dentifrice consumption in an urban population group over 13 years. This study evaluated two surveys of 671 and 688 households sampled in the urban area of a city from Southern Brazil in 1996 and 2009, respectively. The mother of the family was asked to answer a structured questionnaire about demographics, socioeconomic and behavioral variables. The primary outcome was obtained by questioning "how long does a dentifrice tube last in your house?" The cut-off point of duration was less than 1 month. It was used to determine high consumption of dentifrice (HCD). Associations between HCD and independent variables were evaluated by multivariable Poisson regression. There was a significant decrease of 20\% (81.2\% to 61.2\%) in the prevalence of HCD between 1996 and 2009, resulting in a crude annual decrease of 1.54\%. Mother{\textquoteright}s age, family income, dental assistance, mother{\textquoteright}s brushing frequency and number of household members that use a toothbrush were significantly associated with HCD independent from the year of survey. The prevalence ratio (PR) of HCD for the year of survey was 0.75, indicating an overall decrease of 25\% in the probability of HCD from 1996 to 2009. Probabilities of HCD also decreased over the 13 years among the strata of education, number of household members and reason for choice of dentifrice. It may be concluded that the factors associated with the observed decrease were higher educational levels, larger number of household members and reasons for choosing a dentifrice related to preventive/therapeutic effects.

}, keywords = {*Self Report, Adult, Age Factors, Brazil, Dentifrices/*therapeutic use, Educational Status, Family Characteristics, Family Health, Female, Health Behavior, Humans, Income/statistics \& numerical data, Insurance, Dental/statistics \& numerical data, Interviews as Topic, Longitudinal Studies, Maternal Age, Middle Aged, Mothers/education, Social Class, Socioeconomic Factors, Time Factors, Toothbrushing/instrumentation/statistics \& numerical data, Urban Health/statistics \& numerical data}, isbn = {1806-4760 (Electronic)0103-6440 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23338270}, author = {Colussi, P. R. and Haas, A. N. and Oppermann, R. V. and Rosing, C. K.} } @article {718, title = {[Consumption of toothpaste and associated factors in a Brazilian population group]}, journal = {Cad Saude Publica}, volume = {27}, number = {3}, year = {2011}, note = {

Colussi, Paulo Roberto GrafittiHaas, Alex NogueiraOppermann, Rui VicenteRosing, Cassiano KuchenbeckerporEnglish AbstractBrazil2011/04/27 06:00Cad Saude Publica. 2011 Mar;27(3):546-54.

}, month = {Mar}, pages = {546-54}, abstract = {

This cross-sectional study evaluated the consumption of fluoridated dentifrice and associated factors in Passo Fundo, Rio Grande do Sul State, Brazil. A total of 688 households were selected. A structured questionnaire was answered by the mother to obtain demographics, habits, and toothpaste consumption. Household toothpaste consumption was considered low when a tube lasted \> 1 month and high when \< 1 month. Logistic regression models were applied to evaluate the association between consumption and independent variables. 61.2\% of households showed high toothpaste consumption. In the multivariate model, mother{\textquoteright}s age \> 50 years (OR = 1.62; 95\%CI: 1.02-2.61), mother{\textquoteright}s brushing frequency (OR = 2.53; 95\%CI: 1.53-4.16), number of people brushing (OR = 5.69; 95\%CI: 3.68-8.81), and cosmetic features in choice of the dentifrice (OR = 1.64; 95\%CI: 1.03-2.61) showed the highest odds of high toothpaste consumption.

}, keywords = {*Oral Health, Adult, Brazil, Cross-Sectional Studies, Dental Caries/*prevention \& control, Fluorides/*administration \& dosage, Humans, Middle Aged, Mothers/statistics \& numerical data, Questionnaires, Socioeconomic Factors, Toothbrushing/*utilization, Toothpastes/*administration \& dosage, Urban Population}, isbn = {1678-4464 (Electronic)0102-311X (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21519704}, author = {Colussi, P. R. and Haas, A. N. and Oppermann, R. V. and Rosing, C. K.} } @article {717, title = {Prevalence and risk indicators for chronic periodontitis in adolescents and young adults in south Brazil}, journal = {J Clin Periodontol}, volume = {38}, number = {4}, year = {2011}, note = {

Susin, CristianoHaas, Alex NValle, Patricia MOppermann, Rui VAlbandar, Jasim MengResearch Support, Non-U.S. Gov{\textquoteright}tDenmark2011/02/09 06:00J Clin Periodontol. 2011 Apr;38(4):326-33. doi: 10.1111/j.1600-051X.2011.01699.x. Epub 2011 Feb 7.

}, month = {Apr}, pages = {326-33}, abstract = {

AIM: To describe the distribution of clinical attachment loss (CAL) and to study risk indicators for chronic periodontitis in a large population-based sample of adolescents and young adults from south Brazil. MATERIAL AND METHODS: This cross-sectional study used a subset of data from a larger survey representative of Porto Alegre, Brazil. The sample consisted of 612 individuals (291 males/321 females) aged 14-29 years. Full-mouth, six sites per tooth clinical examinations were performed by calibrated periodontists. Chronic periodontitis was defined as CAL 3mm affecting two or more teeth. Aggressive periodontitis cases were excluded from the analysis. RESULTS: CAL 3 and 5mm affected 50.4\% and 17.4\% of subjects and 9.7\% and 1.1\% of teeth, respectively. Prevalence of chronic periodontitis ranged between 18.2\% and 72.0\% among subjects 14-19 and 24-29 years old, respectively. In the multivariable logistic regression analysis, older age [odds ratio (OR)=2.6, 95\% confidence interval (CI)=1.7-3.9 and OR=7.2, 95\% CI=3.7-14.0 for 20-24 and 25-29 years old, respectively], low socioeconomic status (OR=1.9, 95\% CI=1.4-2.7), heavy smoking (OR=1.7, 95\% CI=1.1-2.7) and larger amounts of calculus (OR=2.0, 95\% CI=1.2-3.2) were significantly associated with chronic periodontitis. CONCLUSION: This population of adolescents and young adults had a high prevalence of chronic periodontitis, and its presence was associated with age, socioeconomic status, smoking and calculus.

}, keywords = {Adolescent, Adult, Age Factors, Brazil/epidemiology, Chronic Periodontitis/*epidemiology, Cross-Sectional Studies, Dental Calculus/epidemiology, Dental Care/statistics \& numerical data, Dental Plaque/epidemiology, Educational Status, Female, Gingival Hemorrhage/epidemiology, Humans, Male, Periodontal Attachment Loss/epidemiology, Population Surveillance, Prevalence, Risk Assessment, Sex Factors, Smoking/epidemiology, Social Class, Young Adult}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21299588}, author = {Susin, C. and Haas, A. N. and Valle, P. M. and Oppermann, R. V. and Albandar, J. M.} } @article {719, title = {Proposal for the teaching of the chemical control of supragingival biofilm}, journal = {Braz Oral Res}, volume = {24 Suppl 1}, year = {2010}, note = {

Oppermann, Rui VicenteHaas, Alex NogueiraVilloria, German Eduardo MiguelPrimo, Laura GuimaraesSerra-Negra, Junia MFerreira, Efigenia Ferreira ePannuti, Claudio MendesengBrazil2010/10/05 06:00Braz Oral Res. 2010;24 Suppl 1:33-6.

}, pages = {33-6}, abstract = {

The mechanical control of supragingival biofilm is accepted as one of the most important measures to treat and prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task. In this regard, chemical agents, mainly in the form of mouthwashes, have been studied to help overcome the difficulties involved in the mechanical control of biofilm. The aim of this paper was to discuss proposals for the teaching of supragingival chemical control (SCC) in order to improve dentists{\textquoteright} knowledge regarding this clinical issue. Firstly, the literature regarding the efficacy of antiseptics is presented, clearly showing that chemical agents are clinically effective in the reduction of biofilm and gingival inflammation when used as adjuvant agents to mechanical control. Thus, it is suggested that the content related to SCC be included in the curricular grid of dental schools. Secondly, some essential topics are recommended to be included in the teaching of SCC as follows: skills and competencies expected of a graduate dentist regarding SCC; how to include this content in the curricular grid; teaching-learning tools and techniques to be employed; and program content.

}, keywords = {*Biofilms, Anti-Infective Agents, Local/therapeutic use, Brazil, Dental Caries/prevention \& control, Dental Plaque/*prevention \& control, Education, Dental/*methods, Gingivitis/*prevention \& control, Humans, Mouthwashes/chemistry/therapeutic use, Periodontal Diseases/prevention \& control, Problem-Based Learning}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20857073}, author = {Oppermann, R. V. and Haas, A. N. and Villoria, G. E. and Primo, L. G. and Serra-Negra, J. M. and Ferreira, E. F. and Pannuti, C. M.} } @article {721, title = {Association among menopause, hormone replacement therapy, and periodontal attachment loss in southern Brazilian women}, journal = {J Periodontol}, volume = {80}, number = {9}, year = {2009}, note = {

Haas, Alex NRosing, Cassiano KOppermann, Rui VAlbandar, Jasim MSusin, CristianoengComparative StudyResearch Support, Non-U.S. Gov{\textquoteright}t2009/09/03 06:00J Periodontol. 2009 Sep;80(9):1380-7. doi: 10.1902/jop.2009.090082.

}, month = {Sep}, pages = {1380-7}, abstract = {

BACKGROUND: The aim of the present study was to evaluate the association among menopause, hormone replacement therapy (HRT), and periodontal attachment loss (PAL). METHODS: Three hundred twenty-eight women (40 to 69 years old) who participated in a previous oral survey in South Brazil were included. Women who reported not having their monthly menstrual cycles for \>or=12 months were classified as postmenopausal. Postmenopausal women were categorized according to HRT. Women with \>or=30\% teeth with PAL \>or=5 mm were classified as having periodontitis. The data were analyzed using a multivariable logistic regression model and adjusted for age, smoking, socioeconomic status, and dental care. RESULTS: The prevalence of periodontitis was significantly greater among postmenopausal women not using HRT (HRT-) than among premenopausal women (64.4\% versus 46.3\%; P = 0.005). Similarly, the multivariable analysis demonstrated a significantly higher chance of having periodontitis in postmenopausal HRT- women than in premenopausal women (odds ratio [OR], 2.1; 95\% confidence interval [CI]: 1.1 to 4.0). In contrast, no significant differences were observed in the prevalence of periodontitis between postmenopausal women using HRT (HRT+) and premenopausal women (48.8\% versus 46.3\%; P = 0.77). After adjusting for cofactors, postmenopausal HRT+ women did not have a greater likelihood of having periodontitis than premenopausal women (OR, 1.2; 95\% CI: 0.6 to 2.5). No significant differences in tooth loss were observed among the study groups after adjusting for confounders. CONCLUSIONS: Postmenopausal HRT- women had a greater chance of having periodontitis than premenopausal women. In contrast, postmenopausal HRT+ women and premenopausal women had similar periodontal status. HRT may have a beneficial effect on periodontal health.

}, keywords = {*Estrogen Replacement Therapy, Adult, Age Factors, Aged, Brazil, Dental Care, Female, Humans, Menopause/*physiology, Middle Aged, Periodontal Attachment Loss/*etiology, Periodontitis/etiology, Postmenopause/drug effects/physiology, Premenopause/physiology, Risk Factors, Smoking, Social Class, Tooth Loss/etiology}, isbn = {0022-3492 (Print)0022-3492 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19722786}, author = {Haas, A. N. and Rosing, C. K. and Oppermann, R. V. and Albandar, J. M. and Susin, C.} } @article {720, title = {Professional toothbrushing as a method for diagnosing gingivitis in 3- to 6-year-old preschool children}, journal = {Oral Health Prev Dent}, volume = {7}, number = {4}, year = {2009}, note = {

Mariath, Adriela Azevedo SouzaHaas, Alex NogueiraFischer, Claudia Martinewskide Araujo, Fernando BorbaRosing, Cassiano KuchenbeckerengComparative StudyRandomized Controlled TrialValidation StudiesEngland2009/12/17 06:00Oral Health Prev Dent. 2009;7(4):315-21.

}, pages = {315-21}, abstract = {

PURPOSE: The aim of the present crossover study was to evaluate professional toothbrushing as a method for diagnosing gingivitis in children. MATERIALS AND METHODS: Thirty-four preschool children who had gingival bleeding \> or = 10\% and without proximal restorations/carious lesions were included in the study. Examinations comprised two gingival indices recorded at a 15-min interval, in the following sequences: the Ainamo and Bay gingival bleeding index (GBI1) followed by the brushing index (BI2) and vice versa (BI1-GBI2). Half of the children started the study in the first sequence and the other half in the second. After a 3- to 4-day washout period, the indices were again recorded with individuals changing the sequences. Data analysis considered GBI as the gold standard, and sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) were also calculated. RESULTS: The overall mean value of gingival bleeding at the first examination was 18.85 +/- 9.24\%. Validation of toothbrushing performed after GBI (BI2) resulted in values for SE, SP, PPV and NPV of 0.59 (95\% CI, 0.55 to 0.63), 0.92 (95\% CI, 0.91 to 0.93), 0.64 (95\% CI, 0.60 to 0.69) and 0.90 (95\% CI, 0.89 to 0.92), respectively. BI performed before GBI (BI1) resulted in similar SE, SP, PPV and NPV. Percentage agreement of GBI1-BI2 and BI1-GBI2 was 83.5\% and 85.9\%, respectively. CONCLUSIONS: Professional toothbrushing can be suggested as a method for the diagnosis of gingival inflammatory status in children, especially as an indicator of gingival health.

}, keywords = {Child, Child, Preschool, Cross-Over Studies, Gingival Hemorrhage/diagnosis, Gingivitis/*diagnosis, Humans, Periodontal Index, Predictive Value of Tests, Reproducibility of Results, Sensitivity and Specificity, Toothbrushing/*methods}, isbn = {1602-1622 (Print)1602-1622 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20011748}, author = {Mariath, A. A. and Haas, A. N. and Fischer, C. M. and de Araujo, F. B. and Rosing, C. K.} } @article {722, title = {Professional flossing as a diagnostic method for gingivitis in the primary dentition}, journal = {Braz Oral Res}, volume = {22}, number = {4}, year = {2008}, note = {

Mariath, Adriela Azevedo SouzaBressani, Ana Eliza LemesHaas, Alex NogueiraAraujo, Fernando Borba deRosing, Cassiano KuchenbeckerengValidation StudiesBrazil2009/01/17 09:00Braz Oral Res. 2008 Oct-Dec;22(4):316-21.

}, month = {Oct-Dec}, pages = {316-21}, abstract = {

The aim of this study was to evaluate flossing as a diagnostic method for interproximal gingival bleeding in children. For this crossover study, 23 pre-schoolchildren presenting neither restorations nor approximal carious cavities and with at least 15\% of gingival bleeding sites were selected. Examinations were performed at three different moments (3-4 days interval). Examinations comprised repeated measurements of two gingival indices with a 10-minute interval in the following sequences: the Ainamo \& Bay Gingival Bleeding Index (GBI) followed by the Carter \& Barnes flossing index (CBI); CBI followed by GBI; and GBI followed by GBI. Data analysis was performed only for the interproximal sites, considering the GBI as the gold-standard. Agreement between indices, sensitivity (SE), specificity (SP), positive (PPV) and negative predictive values (NPV) were estimated. Percentage agreements in sequences GBI-CBI, CBI-GBI and GBI-GBI were 70.3\%, 76.4\% and 84.5\%, respectively. Validation of flossing in the first sequence (GBI-CBI) resulted in values of 0.61 (95\%CI 0.53 - 0.68), 0.72 (95\%CI 0.69 - 0.76), 0.33 (95\%CI 0.28 - 0.39) and 0.89 (95\%CI 0.86 - 0.92) respectively for SE, SP, PPV and NPV. It can be concluded that professional flossing is a useful tool in the diagnosis of interproximal gingival inflammatory status in children, especially in conditions of gingival health.

}, keywords = {Child, Child, Preschool, Cross-Over Studies, Dental Devices, Home Care, Dental Plaque/*prevention \& control, Gingival Hemorrhage/*diagnosis, Gingivitis/*diagnosis/prevention \& control, Humans, Periodontal Index, Predictive Value of Tests, Sensitivity and Specificity, Tooth, Deciduous}, isbn = {1807-3107 (Electronic)1806-8324 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19148386}, author = {Mariath, A. A. and Bressani, A. E. and Haas, A. N. and Araujo, F. B. and Rosing, C. K.} } @article {723, title = {Azithromycin as an adjunctive treatment of aggressive periodontitis: 12-months randomized clinical trial}, journal = {J Clin Periodontol}, volume = {35}, number = {8}, year = {2008}, note = {

Haas, Alex Nde Castro, Gabriel DMoreno, TatianaSusin, CristianoAlbandar, Jasim MOppermann, Rui VRosing, Cassiano KengComparative StudyRandomized Controlled TrialResearch Support, Non-U.S. Gov{\textquoteright}tDenmark2008/07/18 09:00J Clin Periodontol. 2008 Aug;35(8):696-704. doi: 10.1111/j.1600-051X.2008.01254.x. Epub 2008 Jul 9.

}, month = {Aug}, pages = {696-704}, abstract = {

AIM: To assess the effect of systemic azithromycin as a supplement to scaling and root planing (SRP) in the treatment of aggressive periodontitis (AgP). MATERIAL AND METHODS: Twenty-four individuals (13-26 years old) underwent a plaque control program, and then were treated with SRP. Subjects were assigned randomly into two groups; the test group used 500 mg azithromycin once a day for 3 days, whereas the control group used a placebo. Clinical variables were assessed at baseline, 3, 6, 9, and 12 months. The periodontal status at baseline and 12 months was compared using the Wald test, and adjusting for the effect of clustering of teeth within subjects. RESULTS: There were no significant differences in visible plaque, gingival bleeding, and supragingival calculus between groups throughout the study. Periodontal probing depth (PPD) and clinical attachment level improved significantly from baseline to 12 months in both groups, with the test group showing significantly more reduction in mean PPD compared with controls (2.88 mm versus 1.85 mm, respectively, p=0.025). Subjects administering azithromycin showed a higher percentage of teeth with attachment gain \>or=1 mm (81.34 versus 63.63, p=0.037), whereas the controls had higher percentage of teeth with attachment loss \>or=1 mm (11.57 versus 2.24, p=0.015). CONCLUSIONS: The adjunctive use of azithromycin has the potential to improve periodontal health of young patients with AgP.

}, keywords = {Adolescent, Adult, Anti-Bacterial Agents/*therapeutic use, Azithromycin/*therapeutic use, Combined Modality Therapy, Dental Calculus/prevention \& control, Dental Plaque/prevention \& control, Dental Scaling, Double-Blind Method, Female, Follow-Up Studies, Gingival Hemorrhage/drug therapy/therapy, Gingival Recession/drug therapy/therapy, Humans, Male, Periodontal Attachment Loss/drug therapy/therapy, Periodontal Pocket/drug therapy/therapy, Periodontitis/*drug therapy/therapy, Placebos, Root Planing, Subgingival Curettage}, isbn = {1600-051X (Electronic)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/18631245}, author = {Haas, A. N. and de Castro, G. D. and Moreno, T. and Susin, C. and Albandar, J. M. and Oppermann, R. V. and Rosing, C. K.} } @article {724, title = {Effect of tongue cleansing on morning oral malodour in periodontally healthy individuals}, journal = {Oral Health Prev Dent}, volume = {5}, number = {2}, year = {2007}, note = {

Haas, Alex NogueiraSilveira, Elcia Maria VarizeRosing, Cassiano KuchenbeckerengRandomized Controlled TrialEngland2007/08/29 09:00Oral Health Prev Dent. 2007;5(2):89-94.

}, pages = {89-94}, abstract = {

PURPOSE: The aim of this randomised single-blind, cross-over trial was to assess the effect of tongue cleansing on morning oral malodour in periodontally healthy subjects. MATERIALS AND METHODS: Ten systemically healthy non-smoker subjects (6 males, 4 females), 24-38 years of age, completed two 4-day periods of oral hygiene cessation with a 7-day wash-out period. In one of these test periods, subjects were instructed to clean their tongues with a tongue scraper 2-3 times a day. Participants presented at least 20 teeth, without cavities, overhanging restorations/prostheses or periodontitis, and had no history of previous periodontal therapy or use of antibiotics in the 3 months prior to the study. Volatile sulphur compounds (VSC; Interscan Halimeter) and organoleptic scores were measured in exhaled mouth air once a day, early in the morning, by one examiner. Comparisons were performed using Wilcoxon{\textquoteright}s signed rank test and Friedman{\textquoteright}s test (alpha = 0.05). RESULTS: VSC levels at baseline were 206.3 ppb (SD 139.8) and 191.4 ppb (SD 127.7) for periods of usage and non-usage of the scraper respectively (p \> 0.05). VSC levels did not change significantly during the 4 days, independent of tongue cleansing (Friedman, p \> 0.05). Only at day 3 did the use of the tongue scraper lead to a significantly lower level of VSC compared with controls (131.1 ppb and 199.3 ppb respectively). No significant differences in organoleptic scores were observed between groups at baseline. During the whole experimental period, there were also no significant changes in organoleptic scores when individuals used or did not use the tongue scraper. CONCLUSION: Tongue cleansing with a scraper was unable to prevent morning oral malodour in the absence of tooth cleaning in periodontally healthy individuals.

}, keywords = {*Biofilms, *Tongue, Adult, Breath Tests/methods, Dental Devices, Home Care, Epidemiologic Methods, Female, Halitosis/etiology/prevention \& control/*therapy, Humans, Male, Oral Hygiene/*methods, Sulfur Compounds/analysis}, isbn = {1602-1622 (Print)1602-1622 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/17722433}, author = {Haas, A. N. and Silveira, E. M. and Rosing, C. K.} } @article {725, title = {Tooth loss in a young population from south Brazil}, journal = {J Public Health Dent}, volume = {66}, number = {2}, year = {2006}, note = {

Susin, CristianoHaas, Alex NOpermann, Rui VAlbandar, Jasim MengResearch Support, Non-U.S. Gov{\textquoteright}t2006/05/23 09:00J Public Health Dent. 2006 Spring;66(2):110-5.

}, month = {Spring}, pages = {110-5}, abstract = {

OBJECTIVES: To assess the prevalence, extent, and risk indicators of tooth loss in a representative young urban population from south Brazil. METHODS: A representative sample was drawn using a multi-stage probability cluster sampling strategy, and consisted of 612 subjects 14-29 years of age in the metropolitan area of Porto Alegre, Brazil. A clinical examination was carried out by 4 calibrated examiners in a mobile examination center. RESULTS: The prevalence of tooth loss was 44.8\%, 26\%, and 60\%, and the mean tooth loss was 1.4, 0.6, and 2.4 teeth in the age groups 14-29, 14-19 and 25-29 years, respectively. First molars were the most frequently missing teeth, and the mandibular incisors and canines were the least missing teeth. Tooth loss increased sharply with age, and was similar in males and females. Having \> or =4 missing teeth was significantly associated with low socioeconomic status and heavy smoking, and was significantly more likely in persons who had \> or =2 teeth with caries/fillings and/or \> or =5 mm attachment loss. CONCLUSION: Tooth loss is a dental health concern in this young Brazilian population. Community-based oral diseases prevention programs targeting groups having these risk factors should be implemented to reduce tooth loss.

}, keywords = {Adolescent, Adult, Age Distribution, Brazil/epidemiology, Dental Caries/epidemiology, Epidemiologic Methods, Female, Humans, Male, Sex Distribution, Smoking/*adverse effects, Social Class, Socioeconomic Factors, Tooth Loss/*epidemiology}, isbn = {0022-4006 (Print)0022-4006 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16711630}, author = {Susin, C. and Haas, A. N. and Opermann, R. V. and Albandar, J. M.} } @article {726, title = {Association between psychosocial factors and periodontitis: a case-control study}, journal = {J Clin Periodontol}, volume = {33}, number = {2}, year = {2006}, note = {

Castro, G D COppermann, R VHaas, A NWinter, RAlchieri, J CengComparative StudyDenmark2006/01/31 09:00J Clin Periodontol. 2006 Feb;33(2):109-14.

}, month = {Feb}, pages = {109-14}, abstract = {

OBJECTIVE: This case-control study investigated the association between life events, anxiety, and depression with periodontitis. METHODOLOGY: The study counted with 165 individuals, both sexes, 35-60 years of age. Case group included 96 individuals suffering from periodontal disease; and in control group 69 subjects with no history of periodontitis. Clinical examinations were performed by a single examiner. Psychological assessment included four inventories: Life Events Scale, Beck Anxiety Inventory, State-Trait Anxiety Inventory and Beck Depression Inventory. Bivariate and multivariate logistic regression analyses were performed to compare cases and controls. RESULTS: Mean probing depth and clinical attachment level were 3.44+/-0.80 and 4.01+/-1.61 in the case group and 1.96+/-0.19 and 0.95+/-0.50 in the control group, respectively (p\<0.05). Positive association of periodontitis with age (odds ratio (OR)=1.15 95\% confidence interval (CI): 1.06-1.24), male gender (OR=2.71, CI: 1.13-6.49), smoking (OR=6.05, CI: 1.67-21.94) and educational level (OR=6.49, CI: 1.14-36.95) was confirmed. Bivariate analysis did not demonstrate significant mean differences in life events, anxiety symptoms, trait or state of anxiety, or depression symptoms between cases and controls. Multivariate logistic regression, controlling for confounding factors, demonstrated no significant association between psychosocial factors and periodontal disease. CONCLUSIONS: Within the limits of this study it is possible to conclude that there was no significant association between periodontitis and the psychosocial factors analysed.

}, keywords = {Adult, Age Factors, Anxiety/classification/psychology, Case-Control Studies, Depression/classification/psychology, Educational Status, Female, Humans, Income, Life Change Events, Male, Middle Aged, Periodontal Attachment Loss/classification/psychology, Periodontal Index, Periodontal Pocket/classification/psychology, Periodontitis/classification/*psychology, Sex Factors, Smoking, Toothbrushing}, isbn = {0303-6979 (Print)0303-6979 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16441734}, author = {Castro, G. D. and Oppermann, R. V. and Haas, A. N. and Winter, R. and Alchieri, J. C.} } @article {727, title = {Gingival recession: epidemiology and risk indicators in a representative urban Brazilian population}, journal = {J Periodontol}, volume = {75}, number = {10}, year = {2004}, note = {

Susin, CristianoHaas, Alex NOppermann, Rui VHaugejorden, OlaAlbandar, Jasim MengResearch Support, Non-U.S. Gov{\textquoteright}t2004/11/26 09:00J Periodontol. 2004 Oct;75(10):1377-86.

}, month = {Oct}, pages = {1377-86}, abstract = {

BACKGROUND: Gingival recession is a common manifestation of periodontal disease, but it is also associated with other risk factors. A few studies have investigated the epidemiology and risk factors of this condition. This study describes the epidemiology of gingival recession in a representative, urban Brazilian population and assesses various risk indicators. METHODS: A representative sample of 1,460 subjects was selected using a multi-stage, probability, cluster sampling strategy. The subjects were interviewed using a structured questionnaire and had a full-mouth clinical examination in a mobile examination center. RESULTS: More than half (51.6\%) and 22.0\% of the individuals and 17.0\% and 5.8\% of teeth per individual showed gingival recession \> or = 3 mm and \> or = 5 mm, respectively. The prevalence, extent, and severity of recession correlated with age. Recession showed a nonlinear relationship with age, with 25 to 50 year olds showing the highest level of recession. Males aged \> or = 30 years showed significantly higher prevalence and extent of gingival recession than females. The percentage of teeth with recession was significantly higher in the lower socioeconomic groups irrespective of age, and in subjects \> or = 30 years of age with irregular dental care than in subjects with regular care. Using a multivariable model, cigarette smoking and presence of supragingival calculus were the factors most significantly associated with localized and generalized recession, whereas gender, dental visits, and socioeconomic status were not significant risk indicators. CONCLUSIONS: The high level of gingival recession in this Brazilian population may be primarily related to destructive periodontal disease and is significantly associated with a high level of supragingival dental calculus and cigarette smoking. Population-based programs aimed at the prevention of periodontal diseases may reduce the prevalence of severe gingival recession in this and similar populations.

}, keywords = {Adolescent, Adult, Age Factors, Aged, Brazil/epidemiology, Continental Population Groups/statistics \& numerical data, Dental Calculus/epidemiology, Dental Care/statistics \& numerical data, Female, Gingival Recession/*epidemiology, Humans, Logistic Models, Male, Middle Aged, Population Surveillance, Prevalence, Reproducibility of Results, Risk Assessment/statistics \& numerical data, Risk Factors, Sex Factors, Smoking/epidemiology, Social Class, Urban Health/*statistics \& numerical data}, isbn = {0022-3492 (Print)0022-3492 (Linking)}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15562916}, author = {Susin, C. and Haas, A. N. and Oppermann, R. V. and Haugejorden, O. and Albandar, J. M.} }